SCHEMBL5065

SCHEMBL5065

[C]1Cc2ccccc2OO1

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.39
MAOB P27338 2/20 0.39
ABCG2 Q9UNQ0 1/20 0.33
ITGB2 P05107 1/20 0.33
ICAM1 P05362 1/20 0.33
ITGAL P20701 1/20 0.33
OXTR P30559 1/20 0.33
GAA P10253 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
LMNA P02545 2/20 0.30
CRHBP P24387 2/20 0.30
CRHR2 Q13324 2/20 0.30
SMN1; SMN2 Q16637 2/20 0.30
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1162929 0.78 MAOA (0.37) MAOAMAOBABCG2ITGB2ICAM1
SCHEMBL141166 0.78 MAOA (0.37) MAOAMAOBABCG2ITGB2ICAM1
SCHEMBL3128 0.76
SCHEMBL2851479 0.76
SCHEMBL231836 0.71 MAOA (0.38) MAOAMAOBABCG2ITGB2ICAM1
SCHEMBL4613477 0.70 MAOA (0.37) MAOAMAOBABCG2ITGB2ICAM1
SCHEMBL7606738 0.67 MAOA (0.70) MAOAMAOBABCG2ITGB2ICAM1
SCHEMBL453819 0.64 MAOA (0.39) MAOAMAOBABCG2ITGB2ICAM1
SCHEMBL3928581 0.64 MAOA (0.39) MAOAMAOBABCG2ITGB2ICAM1
SCHEMBL241643 0.64 OXTR (0.42) MAOAMAOBABCG2ITGB2ICAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 18290 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114829361-B Derivatives having 2, 3-dihydro-1H-indene or 2, 3-dihydrobenzofuran moiety or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same 柳韩洋行 2024-07-16 CN claimed
WO-2024140990-A1 PYRAZOLE FUSED RING COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF 江苏亚虹医药科技股份有限公司 2024-07-04 WO claimed
US-20240208935-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2024-06-27 US claimed
CN-116425717-B C2-site indoline derivative containing quaternary carbon center as well as preparation method and application thereof 重庆医科大学 2024-06-21 CN claimed
CN-118201911-A Compounds and their use as GPR183 inhibitors 南京艾美斐生物医药科技有限公司 2024-06-14 CN claimed
US-20240150358-A1 PURINES AND METHODS OF THEIR USE Kineta, Inc. 2024-05-09 US claimed
EP-4041733-B1 DERIVATIVES HAVING 2,3-DIHYDRO-1H-INDENE OR 2,3-DIHYDROBENZOFURAN MOIETY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME YUHAN CORP (KR) 2024-05-08 EP claimed
US-20240132531-A1 NOVEL GALACTOSIDE INHIBITOR OF GALECTINS GALECTO BIOTECH AB (DK) 2024-04-25 US claimed
EP-4041734-B1 DERIVATIVES HAVING 1,2,3,4-TETRAHYDRONAPHTHALENE MOIETY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME YUHAN CORP (KR) 2024-04-24 EP claimed
US-11963437-B2 Near-infrared light-emitting diode and device including near-infrared light-emitting diode SAMSUNG DISPLAY CO., LTD. (KR) 2024-04-16 US claimed
EP-0038564-A1 Dibenz (b,e) oxepin derivatives and pharmaceutical compositions comprising them KYOWA HAKKO KOGYO CO., LTD (JP) 1981-10-28 EP claimed
EP-0037471-A1 1-Aroyl-2-phenylamino-2-imidazolines, their preparation and their pharmaceutical compositions BASF Aktiengesellschaft (DE) 1981-10-14 EP claimed
EP-0035374-A2 Piperidyl - urea, - thiourea and - guanidine derivatives, and intermediates therefor, processes for preparing them and pharmaceutical compositions containing the derivatives JOHN WYETH & BROTHER LIMITED (GB) 1981-09-09 EP claimed
US-4238496-A ANTIALLERGENS BOEHRINGER INGELHEIM GMBH (DE) 1980-12-09 US claimed
US-4234580-A INSECTICIDES; MITACIDES UNION CARBIDE CORPORATION (US) 1980-11-18 US claimed
US-4221807-A ADRENERGIC BLOCKING AGENTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-09-09 US claimed
US-4180646-A BIOERODABLE SUSTAINED RELEASE COTAINGS ALZA CORPORATION (US) 1979-12-25 US claimed
US-4177272-A HYPOTENSIVE, VASODILATION, PARKINSON'S DISEASE SCIENCE UNION ET CIE (FR) 1979-12-04 US claimed
US-4169894-A INSECTICIDES, MITICIDES, NEMATOCIDES UNION CARBIDE CORPORATION (US) 1979-10-02 US claimed
US-4166864-A MITICIDES, INSECTICIDES UNION CARBIDE CORPORATION (US) 1979-09-04 US claimed