Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5239630 | 0.83 | KDM4E (0.49) | MAPTALDH1A1SMN1; SMN2LMNAPHGDH | |
| SCHEMBL3935054 | 0.82 | SIRT6 (0.53) | MAPTALDH1A1LMNAKCNJ1CYP1A2 | |
| SCHEMBL27472363 | 0.82 | ADRB1 (0.53) | MAPTALDH1A1KCNJ1CYP1A2KDM4E | |
| SCHEMBL5302719 | 0.82 | MAPT (0.43) | MAPTALDH1A1SMN1; SMN2LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL27455896 | 0.81 | ADRB1 (0.51) | MAPTALDH1A1KCNJ1CYP1A2KDM4E | |
| SCHEMBL2085614 | 0.79 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2LMNAKCNJ1 | |
| SCHEMBL6631373 | 0.78 | NPC1 (0.37) | MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4073260 | 0.78 | MGLL (0.41) | MAPTALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL1516145 | 0.78 | ALDH1A1 (0.50) | ALDH1A1LMNA | |
| SCHEMBL12068487 | 0.78 | ALDH1A1 (0.50) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006118749-A1 | THIA-TETRAAZAACENAPHTHYLENE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-11-09 | — | — | WO | disclosed |
| EP-1436291-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | Aventis Pharma S.A. (FR) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003024967-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2003-03-27 | — | — | WO | disclosed |