Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 3/20 | 0.57 |
| ▸ | ERN1 | O75460 | 6/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.52 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1135975 | 0.90 | ERN1 (0.60) | PDK2ERN1KEAP1NFE2L2KMO | |
| SCHEMBL30283775 | 0.90 | ERN1 (0.60) | PDK2ERN1KEAP1NFE2L2KMO | |
| Hydrochloric Acid SCHEMBL28646857 | 0.89 | ERN1 (0.59) | PDK2ERN1KEAP1NFE2L2KMO | |
| Trifluoroacetic Acid SCHEMBL27759146 | 0.85 | CES1 (0.52) | PDK2KIF11CYP3A4MEN1KMT2A | |
| SCHEMBL28022901 | 0.83 | KMO (0.51) | PDK2ERN1KEAP1NFE2L2KMO | |
| Trifluoroacetic Acid SCHEMBL6300559 | 0.82 | KMO (0.75) | PDK2KMOHDAC8 | |
| SCHEMBL27876786 | 0.81 | SMN1; SMN2 (0.55) | PDK2ERN1KMOHDAC8CYP3A4 | |
| SCHEMBL12168605 | 0.81 | ERN1 (0.58) | PDK2ERN1KMO | |
| SCHEMBL22551129 | 0.80 | SLC6A2 (0.54) | PDK2ERN1KEAP1NFE2L2 | |
| SCHEMBL17795214 | 0.79 | ERN1 (0.60) | PDK2ERN1KMOCYP3A4MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954682-A1 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER S DISEASE, NEURODEGENERATION AND DEMENTIA | Astra Zeneca AB (SE) | 2008-08-13 | — | — | EP | claimed |
| WO-2007058601-A1 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | claimed |