SCHEMBL5069484

SCHEMBL5069484

O=C(O)CCCCC(=O)OC(=O)CC/C(=N/O)OC(=O)CCCCC(=O)O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.42
TSHR P16473 5/20 0.41
NFKB1 P19838 2/20 0.41
PMP22 Q01453 1/20 0.41
SLC22A6 Q4U2R8 2/20 0.37
GPR84 Q9NQS5 4/20 0.35
FFAR1 O14842 2/20 0.35
FFAR4 Q5NUL3 2/20 0.35
AKR1B1 P15121 1/20 0.35
CYP2D6 P10635 1/20 0.35
FOLH1 Q04609 1/20 0.35
ALDH1A1 P00352 3/20 0.35
PPARG P37231 5/20 0.34
PPARD Q03181 5/20 0.34
PPARA Q07869 5/20 0.34
HDAC11 Q96DB2 4/20 0.34
TLR2 O60603 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
FABP4 P15090 2/20 0.34
PTPN1 P18031 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15009749 0.98 TSHR (0.44) LMNATSHRNFKB1PMP22SLC22A6
SCHEMBL1247297 0.96 TSHR (0.45) LMNATSHRNFKB1PMP22SLC22A6
SCHEMBL5968591 0.90 EGLN1 (0.39) LMNATSHRSLC22A6FOLH1ALDH1A1
SCHEMBL2335885 0.83 LMNA (0.61) LMNATSHRNFKB1PMP22SLC22A6
SCHEMBL14432755 0.83 DGKA (0.46) LMNATSHRSLC22A6GPR84AKR1B1
SCHEMBL6738571 0.82 ALDH1A1 (0.33) ALDH1A1
SCHEMBL17204502 0.81 DGKA (0.48) LMNATSHRSLC22A6GPR84ALDH1A1
SCHEMBL7887094 0.81 DGKA (0.48) LMNATSHRSLC22A6GPR84ALDH1A1
SCHEMBL7262371 0.81 DGKA (0.48) LMNATSHRSLC22A6GPR84ALDH1A1
SCHEMBL5799523 0.81 TSHR (0.63) LMNATSHRNFKB1PMP22SLC22A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11383006-B2 Bioerodible cross-linked hydrogel implants and related methods of use DOSE MEDICAL CORPORATION (US) 2022-07-12 US claimed
EP-4009857-A1 BIOERODIBLE CROSS-LINKED HYDROGEL IMPLANTS AND RELATED METHODS OF USE DOSE Medical Corporation (US) 2022-06-15 EP claimed
US-20210038769-A1 BIOERODIBLE CROSS-LINKED HYDROGEL IMPLANTS AND RELATED METHODS OF USE DOSE MEDICAL CORPORATION 2021-02-11 US claimed
WO-2021026214-A1 BIOERODIBLE CROSS-LINKED HYDROGEL IMPLANTS AND RELATED METHODS OF USE DOSE MEDICAL CORPORATION (US) 2021-02-11 WO claimed
US-20200375891-A1 BIOERODIBLE CROSS-LINKED HYDROGEL IMPLANTS AND RELATED METHODS OF USE DOSE MEDICAL CORP (US) 2020-12-03 US claimed
WO-2020243602-A1 BIOERODIBLE CROSS-LINKED HYDROGEL IMPLANTS AND RELATED METHODS OF USE DOSE MEDICAL CORPORATION (US) 2020-12-03 WO claimed
US-10550187-B2 Extra luminal scaffold INCEPT, LLC (US) 2020-02-04 US claimed
EP-4344745-A2 SUSTAINED RELEASE BIODEGRADABLE INTRACANALICULAR INSERTS COMPRISING A HYDROGEL AND CYCLOSPORINE Ocular Therapeutix, Inc. (US) 2024-04-03 EP disclosed
US-11938223-B2 Shape changing drug delivery devices and methods INCEPT, LLC (US) 2024-03-26 US disclosed
EP-3973952-B1 SUSTAINED RELEASE BIODEGRADABLE INTRACANALICULAR INSERTS COMPRISING A HYDROGEL AND CYCLOSPORINE OCULAR THERAPEUTIX INC (US) 2024-02-14 EP disclosed
US-20240041758-A1 SUSTAINED RELEASE BIODEGRADABLE INTRACANALICULAR INSERTS COMPRISING A HYDROGEL AND CYCLOSPORINE OCULAR THERAPEUTIX, INC. 2024-02-08 US disclosed
US-11890343-B2 Medical organogel processes and compositions INCEPT, LLC (US) 2024-02-06 US disclosed
EP-4279064-A2 DRUG DELIVERY FROM HYDROGELS Incept, LLC (US) 2023-11-22 EP disclosed
US-20170143636-A1 SHAPE CHANGING DRUG DELIVERY DEVICES AND METHODS OCULAR THERAPEUTIX, INC. 2017-05-25 US disclosed
US-20160331738-A1 DRUG DELIVERY FROM HYDROGELS OCULAR THERAPEUTIX, INC. 2016-11-17 US disclosed
US-20160166504-A1 HYDROGEL DRUG DELIVERY IMPLANTS OCULAR THERAPEUTIX, INC. 2016-06-16 US disclosed
US-20160045602-A1 MEDICAL ORGANOGEL PROCESSES AND COMPOSITIONS OCULAR THERAPEUTIX, INC. 2016-02-18 US disclosed
US-9205150-B2 Medical organogel processes and compositions INCEPT, LLC (US) 2015-12-08 US disclosed
US-20130156752-A1 MEDICAL ORGANOGEL PROCESSES AND COMPOSITIONS INCEPT, LLC (US) 2013-06-20 US disclosed
WO-2008133534-A2 CARBOHYDRATE-LIPID CONSTRUCTS AND THEIR USE IN PREVENTING OR TREATING VIRAL INFECTION KODE BIOTECH LIMITED (NZ) 2008-11-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240041758-A1 SUSTAINED RELEASE BIODEGRADABLE INTRACANALICULAR INSERTS COMPRISING A HYDROGEL AND CYCLOSPORINE SUCLG1, FKBP8, FKBP1A LMNA 3464/4885TSHR 4096/4885NFKB1 2192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.