Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GCK | P35557 | 2/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1793888 | 0.81 | GCK (0.62) | GCKCXCR2MEN1KMT2ANPC1 | |
| SCHEMBL2664550 | 0.77 | HCAR3 (0.52) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5070732 | 0.75 | SGMS2 (0.55) | SGMS2GAAGCKCXCR2MEN1 | |
| SCHEMBL17796443 | 0.73 | XDH (0.45) | RAB9A | |
| SCHEMBL7345966 | 0.69 | GCK (0.72) | SGMS2GAAGCKCXCR2MEN1 | |
| SCHEMBL2653573 | 0.68 | GCK (0.55) | SGMS2GAAGCKCXCR2MEN1 | |
| SCHEMBL7348393 | 0.67 | SGMS2 (0.65) | SGMS2GAAGCKCXCR2MEN1 | |
| SCHEMBL27613370 | 0.67 | SGMS2 (0.65) | SGMS2GAAGCKCXCR2MEN1 | |
| SCHEMBL22351672 | 0.66 | SGMS2 (0.60) | SGMS2GAAMEN1KMT2ATDP1 | |
| SCHEMBL30322922 | 0.66 | SGMS2 (1.00) | SGMS2GAAMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1669068-B1 | Compounds effecting Glucokinase | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | EP | disclosed |