Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | ESRRB | O95718 | 2/20 | 0.38 |
| ▸ | ESRRA | P11474 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 8/20 | 0.37 |
| ▸ | THRB | P10828 | 8/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5072132 | 0.86 | NT5E (0.35) | THRATHRBNT5EKDM4ESLC2A1 | |
| SCHEMBL5072138 | 0.85 | L3MBTL1 (0.38) | ESR1ESR2ESRRBESRRATHRA | |
| SCHEMBL3140925 | 0.82 | THRA (0.45) | THRATHRBKDM4E | |
| SCHEMBL5072159 | 0.78 | THRB (0.39) | ESR1ESR2ESRRBESRRATHRA | |
| SCHEMBL3138232 | 0.78 | SMN1; SMN2 (0.42) | THRATHRB | |
| SCHEMBL30827905 | 0.75 | ACHE (0.49) | THRATHRBKDM4ESLC2A1MAPT | |
| SCHEMBL4745132 | 0.75 | ACHE (0.49) | THRATHRBKDM4ESLC2A1MAPT | |
| SCHEMBL3140938 | 0.73 | THRA (0.46) | THRATHRBKDM4E | |
| SCHEMBL5076613 | 0.73 | KDM4E (0.41) | ESR1ESR2THRATHRBKDM4E | |
| SCHEMBL7692119 | 0.72 | ESR1 (0.64) | ESR1ESR2ESRRBESRRANT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899309-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003419-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2007-01-11 | — | — | WO | disclosed |