Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 14/20 | 0.39 |
| ▸ | THRA | P10827 | 12/20 | 0.39 |
| ▸ | ESRRB | O95718 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESRRA | P11474 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5072151 | 0.89 | THRB (0.40) | THRBTHRA | |
| SCHEMBL3128285 | 0.82 | THRB (0.43) | THRBTHRA | |
| SCHEMBL5072134 | 0.78 | ESR1 (0.38) | THRBTHRAESRRBESR1ESRRA | |
| SCHEMBL5076613 | 0.75 | KDM4E (0.41) | THRBTHRAESR1ESR2 | |
| SCHEMBL5072138 | 0.74 | L3MBTL1 (0.38) | THRBTHRAESRRBESR1ESRRA | |
| SCHEMBL6104751 | 0.73 | KDM4E (0.50) | — | |
| SCHEMBL5074426 | 0.71 | CYP1A2 (0.44) | THRBTHRA | |
| SCHEMBL6089328 | 0.71 | HTT (0.44) | — | |
| SCHEMBL3140938 | 0.71 | THRA (0.46) | THRBTHRA | |
| SCHEMBL9623386 | 0.70 | MEN1 (0.54) | THRBTHRAESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899309-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003419-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2007-01-11 | — | — | WO | disclosed |