Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.54 |
| ▸ | GUSB | P08236 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.47 |
| ▸ | HTR3B | O95264 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR3A | P46098 | 2/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2459199 | 0.99 | HTR7 (0.53) | HTR7GUSBHTR6SIGMAR1HTR3E | |
| SCHEMBL8985943 | 0.79 | ADRB1 (0.57) | HTR7HTR6SIGMAR1HTR3EHTR3B | |
| SCHEMBL4199194 | 0.77 | HTR7 (0.48) | HTR7SIGMAR1ALDH1A1KCNH2DRD3 | |
| SCHEMBL475387 | 0.75 | HDAC4 (0.61) | HTR7HTR6SIGMAR1HTR3EHTR3B | |
| SCHEMBL7672095 | 0.75 | SIGMAR1 (0.53) | HTR7SIGMAR1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL17276711 | 0.74 | ADRB1 (0.67) | HTR7HTR6SIGMAR1HTR3EHTR3B | |
| SCHEMBL14345460 | 0.74 | CYP1A2 (0.62) | HTR7ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6238716 | 0.74 | MEN1 (0.51) | HTR7ALDH1A1HDAC4MEF2DMAPT | |
| SCHEMBL2457437 | 0.74 | GPR119 (0.51) | HTR7ALDH1A1MAPT | |
| SCHEMBL13345895 | 0.73 | HTR7 (0.57) | HTR7HTR6SIGMAR1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2131656-A2 | PHTHALAZINE DERIVATIVES | Forest Laboratories Holdings Limited (BM) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008061108-A2 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-05-22 | — | — | WO | disclosed |