Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7827660 | 0.87 | PARP1 (0.35) | CYP19A1CYP11B1CYP11B2KCNH2SIGMAR1 | |
| Bromide SCHEMBL7991329 | 0.86 | PARP1 (0.34) | CYP19A1CYP11B1CYP11B2KCNH2SIGMAR1 | |
| SCHEMBL27690826 | 0.77 | HDAC3 (0.42) | ATMRAB9ANPC1SIGMAR1KMT2A | |
| SCHEMBL3717732 | 0.74 | MAPK14 (0.33) | — | |
| SCHEMBL27762859 | 0.74 | PARP1 (0.34) | — | |
| SCHEMBL5081250 | 0.73 | HRH1 (0.37) | KCNH2SIGMAR1KMT2AMAPTMEN1 | |
| SCHEMBL3714749 | 0.73 | P2RX7 (0.33) | — | |
| SCHEMBL28048323 | 0.72 | HTR1A (0.31) | KMT2AMEN1 | |
| SCHEMBL3720425 | 0.72 | FABP1 (0.37) | KCNH2 | |
| Bromide SCHEMBL28246683 | 0.71 | HTR1A (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101443315-B | bicyclic heteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS INC | 2012-08-29 | — | — | CN | disclosed |
| CN-101443315-A | Bicyclic heteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS INC (US) | 2009-05-27 | — | — | CN | disclosed |
| EP-1937643-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007109160-A9 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS INC (US) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007109160-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |