Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5075152 | 0.79 | ALDH1A1 (0.51) | KMT2ACYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL7827660 | 0.79 | PARP1 (0.35) | SIGMAR1KMT2ACYP1A2ALDH1A1MEN1 | |
| Bromide SCHEMBL7991329 | 0.78 | PARP1 (0.34) | SIGMAR1KMT2ACYP1A2ALDH1A1MEN1 | |
| SCHEMBL5072999 | 0.73 | ATM (0.36) | SIGMAR1KMT2AMEN1KCNH2LMNA | |
| SCHEMBL27762859 | 0.72 | PARP1 (0.34) | PARP1 | |
| SCHEMBL28048323 | 0.71 | HTR1A (0.31) | KMT2AALDH1A1MEN1 | |
| SCHEMBL3720425 | 0.70 | FABP1 (0.37) | KCNH2GRIN1GRIN2B | |
| Bromide SCHEMBL28246683 | 0.70 | HTR1A (0.30) | — | |
| SCHEMBL14480111 | 0.68 | ALDH1A1 (0.49) | HRH1KMT2ACYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL5077566 | 0.68 | HDAC3 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001474-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007109172-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |