Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.50 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | TACR2 | P21452 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10584058 | 0.83 | ACHE (0.37) | CYP1A2CYP2D6TSHRCYP2C19SMN1; SMN2 | |
| SCHEMBL6585059 | 0.81 | MGLL (0.43) | LMNACYP1A2CYP2D6MAPK1CYP2C19 | |
| SCHEMBL20535808 | 0.81 | APP (0.34) | LTA4HLMNACYP1A2CYP2D6TSHR | |
| SCHEMBL4872803 | 0.81 | CYP19A1 (0.34) | LTA4HNR5A1LMNACYP1A2CYP2D6 | |
| SCHEMBL8904260 | 0.81 | TDP1 (0.44) | LMNACYP1A2TSHRMAPK1CYP2C19 | |
| SCHEMBL8904259 | 0.81 | CYP2D6 (0.33) | LTA4HNR5A1LMNACYP1A2CYP2D6 | |
| SCHEMBL6987433 | 0.81 | LTA4H (0.46) | LTA4HESR1LMNACYP1A2CYP2D6 | |
| SCHEMBL8712246 | 0.79 | THRB (0.33) | LMNACYP1A2CYP2D6TSHRCYP2C19 | |
| SCHEMBL3128008 | 0.78 | CYP3A4 (0.30) | CYP1A2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL15867098 | 0.78 | NQO1 (0.36) | LTA4HLMNACYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891080-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128055-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |
| WO-1996040614-A1 | PROTEIN KINASE C MODULATORS .X. | PROCYON PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |