Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | ALB | P02768 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 4/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30667453 | 0.80 | LMNA (0.46) | LMNAALBALDH1A1POLBBLM | |
| Dexelvucitabine SCHEMBL599014 | 0.80 | ALB (0.55) | LMNAALBALDH1A1POLBBLM | |
| SCHEMBL4749034 | 0.80 | LMNA (0.59) | LMNAALBALDH1A1POLBBLM | |
| Elvucitabine SCHEMBL3298257 | 0.80 | ALB (0.55) | LMNAALBALDH1A1POLBBLM | |
| SCHEMBL5952944 | 0.80 | LMNA (0.59) | LMNAALBALDH1A1POLBBLM | |
| Elvucitabine SCHEMBL1649928 | 0.80 | ALB (0.55) | LMNAALBALDH1A1POLBBLM | |
| SCHEMBL5074429 | 0.79 | ALB (0.39) | LMNAALBALDH1A1POLBBLM | |
| SCHEMBL5074416 | 0.78 | ALB (0.39) | LMNAALBALDH1A1POLBBLM | |
| SCHEMBL7124525 | 0.78 | BLM (0.63) | LMNAALBALDH1A1POLBBLM | |
| SCHEMBL5076232 | 0.75 | ABL1 (0.45) | LMNAALBALDH1A1POLBDNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293668-A1 | [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides | SCHINAZI RAYMOND F | 2008-11-27 | — | — | US | claimed |
| US-20040167140-A1 | [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides | EMORY UNIVERSITY | 2004-08-26 | — | — | US | claimed |
| EP-1361227-A2 | [5-carboxamide or 5-fluoro]-[2', 3'-unsaturated or 3'-modifield]-pyrimidine nucleosides | Emory University (US) | 2003-11-12 | — | — | EP | claimed |
| US-20020198173-A1 | [5-carboxamido or 5-fluoro] - [2' ,3' -unsaturated or 3' -modified] - pyrimidine nucleosides | EMORY UNIVERSITY | 2002-12-26 | — | — | US | claimed |
| US-20080293668-A1 | [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides | SCHINAZI RAYMOND F | 2008-11-27 | — | — | US | disclosed |
| US-7419966-B2 | [5-carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides | EMORY UNIVERSITY (US) | 2008-09-02 | — | — | US | disclosed |
| US-20040167140-A1 | [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides | EMORY UNIVERSITY | 2004-08-26 | — | — | US | disclosed |
| US-6680303-B2 | VIRICIDES FOR TREATING HIV AND HEPATITIS VIRUS | EMORY UNIVERSITY | 2004-01-20 | — | — | US | disclosed |
| EP-1361227-A2 | [5-carboxamide or 5-fluoro]-[2', 3'-unsaturated or 3'-modifield]-pyrimidine nucleosides | Emory University (US) | 2003-11-12 | — | — | EP | disclosed |
| US-20020198173-A1 | [5-carboxamido or 5-fluoro] - [2' ,3' -unsaturated or 3' -modified] - pyrimidine nucleosides | EMORY UNIVERSITY | 2002-12-26 | — | — | US | disclosed |
| US-6391859-B1 | HUMAN IMMUNODEFICIENCY VIRUS; VIRICIDES | EMORY UNIVERSITY | 2002-05-21 | — | — | US | disclosed |
| US-6232300-B1 | ADMINISTERING AS HEPATITIS B VIRICIDE | EMORY UNIVERSITY | 2001-05-15 | — | — | US | disclosed |
| US-5905070-A | HUMAN T-CELL LEUKEMIA/LYMPHOMA AND HEPATITIS B VIRICIDES; AIDS | EMORY UNIVERSITY (US) | 1999-05-18 | — | — | US | disclosed |
| US-5703058-A | TREATMENT OF HIV AND HEPATITIS B | EMORY UNIVERSITY (US) | 1997-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293668-A1 | [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides | DUT, NUDT1, PNP | LMNA 1598/4885ALB 1099/4885ALDH1A1 1880/4885 |
| US-20020198173-A1 | [5-carboxamido or 5-fluoro] - [2' ,3' -unsaturated or 3' -modified] - pyrimidine nucleosides | DUT, NUDT1, PNP | LMNA 1735/4885ALB 1169/4885ALDH1A1 1716/4885 |
| US-20040167140-A1 | [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides | DUT, NUDT1, PNP | LMNA 1735/4885ALB 1169/4885ALDH1A1 1716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.