Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | APEX1 | P27695 | 1/20 | 0.61 |
| ▸ | MTOR | P42345 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4258203 | 1.00 | KDM4E (0.64) | KDM4ELMNAHIF1AADRA2AADRA2C | |
| SCHEMBL14465577 | 1.00 | KDM4E (0.64) | KDM4ELMNAHIF1AADRA2AADRA2C | |
| SCHEMBL2252628 | 1.00 | KDM4E (0.64) | KDM4ELMNAHIF1AADRA2AADRA2C | |
| SCHEMBL5174891 | 1.00 | KDM4E (0.64) | KDM4ELMNAHIF1AADRA2AADRA2C | |
| SCHEMBL1262889 | 1.00 | KDM4E (0.64) | KDM4ELMNAHIF1AADRA2AADRA2C | |
| SCHEMBL723104 | 1.00 | KDM4E (0.64) | KDM4ELMNAHIF1AADRA2AADRA2C | |
| Hydrochloric Acid SCHEMBL5082770 | 0.98 | ALDH1A1 (0.65) | KDM4ELMNAHIF1AADRA2AADRA2C | |
| Hydrochloric Acid SCHEMBL1168030 | 0.98 | ALDH1A1 (0.65) | KDM4ELMNAHIF1AADRA2AADRA2C | |
| Hydrochloric Acid SCHEMBL5082784 | 0.98 | ALDH1A1 (0.65) | KDM4ELMNAHIF1AADRA2AADRA2C | |
| Hydrochloric Acid SCHEMBL7327569 | 0.98 | ALDH1A1 (0.65) | KDM4ELMNAHIF1AADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110105346-B | Optionally substituted quinoline compounds | 卫材R&D管理有限公司 | 2023-03-10 | — | — | CN | disclosed |
| EP-3626717-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | Eisai R&D Management Co., Ltd. (JP) | 2020-03-25 | — | — | EP | disclosed |
| US-RE47193-E1 | Selectively substituted quinoline compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2019-01-08 | — | — | US | disclosed |
| US-20180354939-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-12-13 | — | — | US | disclosed |
| US-10087174-B2 | Selectively substituted quinoline compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-10-02 | — | — | US | disclosed |
| US-20180030045-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-02-01 | — | — | US | disclosed |
| US-20160326161-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-11-10 | — | — | US | disclosed |
| US-9428495-B2 | Selectively substituted quinoline compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-08-30 | — | — | US | disclosed |
| US-20150105370-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-16 | — | — | US | disclosed |
| US-7408084-B2 | Process for producing optically active β-amino alcohol | KANEKA CORPORATION (JP) | 2008-08-05 | — | — | US | disclosed |
| US-20050277791-A1 | Process for producing optically active beta-amino alcohol | KANEKA CORPORATION (JP) | 2005-12-15 | — | — | US | disclosed |
| EP-1512677-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE s-AMINO ALCOHOL | KANEKA CORPORATION (JP) | 2005-03-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10087174-B2 | Selectively substituted quinoline compounds | SSB, TLR7, TLR8 | KDM4E 562/4885LMNA 1606/4885HIF1A 3436/4885 |
| US-20180030045-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | SSB, TLR7, TLR8 | KDM4E 562/4885LMNA 1606/4885HIF1A 3436/4885 |
| US-20180354939-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | SSB, TLR7, TLR8 | KDM4E 541/4885LMNA 1330/4885HIF1A 3472/4885 |
| US-20160326161-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | SSB, TLR7, TLR8 | KDM4E 562/4885LMNA 1606/4885HIF1A 3436/4885 |
| US-20150105370-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | SSB, TLR7, TLR8 | KDM4E 562/4885LMNA 1606/4885HIF1A 3436/4885 |
| US-20050277791-A1 | Process for producing optically active beta-amino alcohol | ADH1A, ALDH7A1, ADH1C | KDM4E 1301/4885LMNA 1549/4885HIF1A 3180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.