Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 4/20 | 0.34 |
| ▸ | ACHE | P22303 | 4/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5076613 | 0.88 | KDM4E (0.41) | KDM4EMEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL5072131 | 0.86 | L3MBTL1 (0.38) | KDM4EL3MBTL1PLA2G10THRATHRB | |
| SCHEMBL3142072 | 0.84 | ALOX15 (0.43) | KDM4EMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL5072138 | 0.74 | L3MBTL1 (0.38) | KDM4EL3MBTL1ALDH1A1HPGDPLA2G10 | |
| SCHEMBL7691857 | 0.73 | L3MBTL1 (0.60) | KDM4EMEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL5072151 | 0.73 | THRB (0.40) | THRATHRB | |
| SCHEMBL5072132 | 0.73 | NT5E (0.35) | KDM4EMEN1KMT2AALDH1A1THRA | |
| SCHEMBL3140799 | 0.71 | THRA (0.42) | KDM4EMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL5074424 | 0.69 | CYP1A2 (0.44) | KDM4EMEN1KMT2ATHRATHRB | |
| SCHEMBL7699246 | 0.69 | KDM4E (0.49) | KDM4EMEN1KMT2ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899309-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003419-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2007-01-11 | — | — | WO | disclosed |