Sugi Predict

Sugi Predict / Compounds / Succinic Acid

Succinic Acid

Succinic Acid

SCHEMBL507817

CN(c1ccc2c(c1)CCO2)c1c(Cl)ccc2c1CCNCC2.O=C(O)CCC(=O)O

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EGFR known ✓ P00533 1/20 0.35
▸ HTR2A known ✓ P28223 1/20 0.35
▸ HTR2C known ✓ P28335 1/20 0.35
▸ SLC6A9 P48067 2/20 0.39
▸ FABP4 P15090 10/20 0.37
▸ PDGFRB P09619 1/20 0.35
▸ KDR P35968 1/20 0.35
▸ HTR2B P41595 1/20 0.35
▸ FFAR1 O14842 1/20 0.35
▸ KEAP1 Q14145 1/20 0.34
▸ NFE2L2 Q16236 1/20 0.34
▸ FABP3 P05413 3/20 0.34
▸ PRKAB2 O43741 2/20 0.33
▸ PRKAG1 P54619 2/20 0.33
▸ PRKAA2 P54646 2/20 0.33
▸ PRKAA1 Q13131 2/20 0.33
▸ PRKAG3 Q9UGI9 2/20 0.33
▸ PRKAG2 Q9UGJ0 2/20 0.33
▸ PRKAB1 Q9Y478 2/20 0.33
▸ FABP5 Q01469 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Succinic Acid SCHEMBL506423 0.85 DAGLA (0.39) HTR2AHTR2CHTR2B
Succinic Acid SCHEMBL507209 0.82 HTR2B (0.39) HTR2AHTR2CHTR2B
Succinic Acid SCHEMBL506561 0.80 HTR2B (0.34) HTR2AHTR2CHTR2B
Succinic Acid SCHEMBL506535 0.76 HTR2B (0.36) HTR2AHTR2CHTR2BADRA2AADRA2B
Succinic Acid SCHEMBL506941 0.75 RXRA (0.37) HTR2AHTR2CHTR2B
SCHEMBL507264 0.75 PKM (0.41) SLC6A9FABP4EGFRPDGFRBKDR
Succinic Acid SCHEMBL2369375 0.73 HTR2B (0.33) HTR2AHTR2CHTR2B
Succinic Acid SCHEMBL508021 0.73 LTC4S (0.34) HTR2AHTR2CHTR2B
Succinic Acid SCHEMBL507308 0.73 LTC4S (0.44) HTR2AHTR2CHTR2B
Succinic Acid SCHEMBL507602 0.72 HTR2C (0.42) HTR2AHTR2CHTR2BADRA2AADRA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1720836-B1 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS LILLY CO ELI (US) 2014-04-16 — — EP disclosed
US-8580780-B2 6 substituted 2, 3,4,5 tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonist ELI LILLY AND COMPANY (US) 2013-11-12 — — US disclosed
EP-2479168-A1 6-Substituted 2,3,4,5-Tetrahydro-1H-Benzo [d]Azepines as 5-HT2C Receptor Agonists ELI LILLY AND COMPANY (US) 2012-07-25 — — EP disclosed
US-20120028961-A1 6 Substituted 2, 3,4,5 Tetrahydro-1H-Benzo[d]Azepines as 5-HT2c Receptor Agonist ELI LILLY AND COMPANY (US) 2012-02-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120028961-A1 6 Substituted 2, 3,4,5 Tetrahydro-1H-Benzo[d]Azepines as 5-HT2c Receptor Agonist HTR2C, HTR4, HTR1A EGFR 415/4885HTR2A 4/4885HTR2C 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.