Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 9/20 | 0.60 |
| ▸ | NOS3 | P29474 | 5/20 | 0.60 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL422030 | 0.89 | NOS1 (0.58) | NOS1NOS3NOS2 | |
| SCHEMBL8275585 | 0.88 | NOS1 (0.45) | NOS1NOS3 | |
| SCHEMBL5080890 | 0.86 | NOS1 (0.59) | NOS1NOS3NOS2 | |
| SCHEMBL419682 | 0.84 | NOS1 (0.57) | NOS1NOS3NOS2 | |
| SCHEMBL7073206 | 0.83 | NOS1 (0.60) | NOS1NOS3NOS2 | |
| SCHEMBL8275628 | 0.82 | NOS1 (0.54) | NOS1NOS3NOS2 | |
| SCHEMBL6585068 | 0.80 | NOS1 (0.46) | NOS1NOS3NOS2 | |
| SCHEMBL8471365 | 0.79 | NOS1 (0.51) | NOS1NOS3NOS2 | |
| SCHEMBL5776507 | 0.77 | NOS1 (0.68) | NOS1NOS3NOS2 | |
| SCHEMBL14265508 | 0.76 | NOS1 (0.74) | NOS1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434624-B1 | 2-AMINO-6-(2,4,5-SUBSTITUTED-PHENYL)-PYRIDINES FOR USE AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PROD INC (US) | 2006-11-02 | — | — | EP | claimed |
| US-20050032847-A1 | 2-amino-6(2,4,5-substitued-phenyl)-pyridines | PFIZER INC. | 2005-02-10 | — | — | US | claimed |
| US-6803470-B2 | NITRIC OXIDE SYNTHASE INHIBITORS. | PFIZER INC | 2004-10-12 | — | — | US | claimed |
| EP-1434624-A1 | 2-AMINO-6-(2,4,5-SUBSTITUTED-PHENYL)-PYRIDINES FOR USE AS NITRIC OXIDE SYNTHASE INHIBITORS | Pfizer Products Inc. (US) | 2004-07-07 | — | — | EP | claimed |
| US-20030087891-A1 | 2-Amino-6-(2,4,5-substituted-phenyl)-pyridines | PFIZER INC. | 2003-05-08 | — | — | US | claimed |
| WO-2003030993-A1 | 2-AMINO-6-(2,4,5-SUBSTITUTED-PHENYL)-PYRIDINES FOR USE AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-04-17 | — | — | WO | claimed |
| US-20080070952-A1 | Inhibition or Treatment of Dyskinesia | PROXIMAGEN LTD., (GB) | 2008-03-20 | — | — | US | disclosed |
| US-20080070952-A1 | Inhibition or Treatment of Dyskinesia | PROXIMAGEN LTD., (GB) | 2008-03-20 | — | — | US | disclosed |
| EP-1434624-B1 | 2-AMINO-6-(2,4,5-SUBSTITUTED-PHENYL)-PYRIDINES FOR USE AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PROD INC (US) | 2006-11-02 | — | — | EP | disclosed |
| EP-1434624-B1 | 2-AMINO-6-(2,4,5-SUBSTITUTED-PHENYL)-PYRIDINES FOR USE AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PROD INC (US) | 2006-11-02 | — | — | EP | disclosed |
| US-20060058267-A1 | Pharmaceutical compositions comprising a NOS inhibitor | PFIZER INC | 2006-03-16 | — | — | US | disclosed |
| EP-1596861-A1 | PHARMACEUTICAL COMBINATIONS COMPRISING A NOS INHIBITOR AND AN NMDA RECEPTOR ANTAGONIST | Pfizer Products Inc. (US) | 2005-11-23 | — | — | EP | disclosed |
| US-20050032847-A1 | 2-amino-6(2,4,5-substitued-phenyl)-pyridines | PFIZER INC. | 2005-02-10 | — | — | US | disclosed |
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | PFIZER INC. | 2004-04-22 | — | — | US | disclosed |
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | PFIZER INC. | 2004-04-22 | — | — | US | disclosed |
| US-20030087891-A1 | 2-Amino-6-(2,4,5-substituted-phenyl)-pyridines | PFIZER INC. | 2003-05-08 | — | — | US | disclosed |
| US-20030087891-A1 | 2-Amino-6-(2,4,5-substituted-phenyl)-pyridines | PFIZER INC. | 2003-05-08 | — | — | US | disclosed |
| WO-2003030993-A1 | 2-AMINO-6-(2,4,5-SUBSTITUTED-PHENYL)-PYRIDINES FOR USE AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-04-17 | — | — | WO | disclosed |
| WO-2003030993-A1 | 2-AMINO-6-(2,4,5-SUBSTITUTED-PHENYL)-PYRIDINES FOR USE AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-04-17 | — | — | WO | disclosed |
| WO-2003030993-A1 | 2-AMINO-6-(2,4,5-SUBSTITUTED-PHENYL)-PYRIDINES FOR USE AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058267-A1 | Pharmaceutical compositions comprising a NOS inhibitor | NOS1, NOS2, NOS3 | NOS1 1/4885NOS3 3/4885NOS2 2/4885 |
| US-20080070952-A1 | Inhibition or Treatment of Dyskinesia | DBH, COMT, DDO | NOS1 15/4885NOS3 18/4885NOS2 29/4885 |
| US-20030087891-A1 | 2-Amino-6-(2,4,5-substituted-phenyl)-pyridines | PNMT, HTR6, HTR2C | NOS1 2251/4885NOS3 1089/4885NOS2 1257/4885 |
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | NOS3, NOS1, NOS2 | NOS1 2/4885NOS3 1/4885NOS2 3/4885 |
| US-20050032847-A1 | 2-amino-6(2,4,5-substitued-phenyl)-pyridines | PNMT, HTR6, HTR2C | NOS1 2336/4885NOS3 1069/4885NOS2 1214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.