SCHEMBL508488

SCHEMBL508488

N=C(N)NOC(=O)C(F)(F)F

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL508258 0.85
SCHEMBL3906654 0.82 CA2 (0.32) CA2
SCHEMBL508399 0.81
SCHEMBL6507208 0.78 TAS2R38 (0.32)
SCHEMBL1507929 0.77 CA2 (0.43) CA2
SCHEMBL1332813 0.75
SCHEMBL6983915 0.75 CA2 (0.31) CA2
SCHEMBL2286616 0.75 ALDH1A1 (0.30)
SCHEMBL28109785 0.75 ALDH1A1 (0.30)
SCHEMBL508234 0.75 NOS1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115915795-A Perovskite solar cell containing double-layer trifluoroacetate modification layer and preparation method thereof 河北工业大学 2023-04-04 CN claimed
US-8425702-B2 Precursor of an explosive composition including at least one ionic liquid and a method of desensitizing an explosive composition ALLIANT TECHSYSTEMS INC. (US) 2013-04-23 US claimed
US-20120024437-A1 PRECURSOR OF AN EXPLOSIVE COMPOSITION INCLUDING AT LEAST ONE IONIC LIQUID AND A METHOD OF DESENSITIZING AN EXPLOSIVE COMPOSITION ALLIANT TECHSYSTEMS INC. (US) 2012-02-02 US claimed
US-8012277-B2 Mixture with activator; desentization melt ALLIANT TECHSYSTEMS INC. (US) 2011-09-06 US claimed
US-20080251169-A1 IONIC LIQUID, A METHOD OF SYNTHESIZING AN IONIC LIQUID, A PRECURSOR OF AN EXPLOSIVE COMPOSITION INCLUDING AT LEAST ONE IONIC LIQUID, AND A METHOD OF DESENSITIZING AN EXPLOSIVE COMPOSITION ALLIANT TECHSYSTEMS INC. (US) 2008-10-16 US claimed
US-12516892-B2 Inverted barocaloric effects PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2026-01-06 US disclosed
US-12398132-B2 Derivatives of 4-(imidazo[1,2-a]pyridin-3-yl)-n-(pyridinyl)pyrimidin-2-amine as therapeutic agents AUCENTRA THERAPEUTICS PTY LTD (AU) 2025-08-26 US disclosed
EP-4602126-A1 INVERTED BAROCALORIC EFFECTS President and Fellows of Harvard College (US) 2025-08-20 EP disclosed
WO-2024081374-A9 INVERTED BAROCALORIC EFFECTS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2025-05-22 WO disclosed
US-20250059178-A1 N-(PYRIDIN-2-YL)-4-(THIAZOL-5-YL)PYRIMIDIN-2-AMINE DERIVATIVES AS THERAPEUTIC COMPOUNDS Aucentra Thereapeutics Pty LTD (AU) 2025-02-20 US disclosed
US-20250012516-A1 INVERTED BAROCALORIC EFFECTS PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2025-01-09 US disclosed
CN-114269742-B Derivatives of 4- (imidazo [1,2-a ] pyridin-3-yl) -N- (pyridinyl) pyrimidin-2-amine as therapeutic agents 常州千红生化制药股份有限公司 2024-07-16 CN disclosed
CN-1351602-A Novel Pharmaceutically Active Compounds ASTRAZENECA AB (SE) 2002-05-29 CN disclosed
EP-0805685-B1 NOVEL ANTIFUNGAL CYCLOHEXAPEPTIDES MERCK & CO INC (US) 2001-09-26 EP disclosed
CN-1289326-A N-[(substituted five-membered di-or thiaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia PFIZER PROD INC (US) 2001-03-28 CN disclosed
CN-1237961-A Aminoguanidines and alkoxyguanidines as protease inhibitors DIMENSIONAL PHARM INC (US) 1999-12-08 CN disclosed
US-5854213-A Antifungal cyclohexapeptides MERCK & CO., INC. (US) 1998-12-29 US disclosed
EP-0805685-A4 NOVEL ANTIFUNGAL CYCLOHEXAPEPTIDES MERCK & CO INC (US) 1998-04-29 EP disclosed
EP-0805685-A1 NOVEL ANTIFUNGAL CYCLOHEXAPEPTIDES Merck & Co., Inc. (US) 1997-11-12 EP disclosed
WO-1996022784-A1 NOVEL ANTIFUNGAL CYCLOHEXAPEPTIDES MERCK & CO., INC. (US) 1996-08-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250059178-A1 N-(PYRIDIN-2-YL)-4-(THIAZOL-5-YL)PYRIMIDIN-2-AMINE DERIVATIVES AS THERAPEUTIC COMPOUNDS CDK4, CDK6, CDK2 CA2 4750/4885
US-12398132-B2 Derivatives of 4-(imidazo[1,2-a]pyridin-3-yl)-n-(pyridinyl)pyrimidin-2-amine as therapeutic agents FLT3, CDK2, CDK4 CA2 4678/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.