Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 known ✓ | P30411 | 4/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5088545 | 0.98 | MEN1 (0.42) | BDKRB2HIF1AMEN1KMT2ATP53 | |
| Iodide SCHEMBL5091883 | 0.96 | HIF1A (0.41) | BDKRB2HIF1AMEN1KMT2ATP53 | |
| Bromide SCHEMBL5087698 | 0.96 | BDKRB2 (0.41) | BDKRB2HIF1ACSNK1ECNR2SIGMAR1 | |
| Iodide SCHEMBL11105595 | 0.94 | CSNK1E (0.41) | HIF1AMEN1KMT2ATP53MAPK1 | |
| Bromide SCHEMBL5859727 | 0.94 | DNM1 (0.43) | BDKRB2HIF1AMEN1KMT2ATP53 | |
| Bromide SCHEMBL5091727 | 0.94 | DNM1 (0.43) | BDKRB2HIF1AMEN1KMT2ATP53 | |
| Iodide SCHEMBL5086690 | 0.94 | CSNK1E (0.41) | HIF1AMEN1KMT2ATP53MAPK1 | |
| Water SCHEMBL4392333 | 0.94 | CSNK1E (0.41) | HIF1AMEN1KMT2ATP53MAPK1 | |
| Hydrochloric Acid SCHEMBL5091573 | 0.93 | HIF1A (0.42) | BDKRB2HIF1AMEN1KMT2ATP53 | |
| SCHEMBL7872914 | 0.92 | CES2 (0.41) | HIF1AMEN1KMT2ATP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214386-A1 | Stability; easily separated from solution; surface treatment of catalyst with Group seven compound; reacting epoxide with carbon dioxide | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2008-09-04 | — | — | US | disclosed |