Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | OGG1 | O15527 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL28791012 | 0.90 | TSHR (0.57) | TP53TSHRCES2CES1KMT2A | |
| Terephthalic Acid SCHEMBL10938231 | 0.90 | TSHR (0.57) | TP53TSHRCES2CES1KMT2A | |
| Terephthalic Acid SCHEMBL855281 | 0.90 | TSHR (0.57) | TP53TSHRCES2CES1KMT2A | |
| SCHEMBL1071444 | 0.89 | RXRA (0.49) | RXRARXRBTP53TSHRCES2 | |
| SCHEMBL4576706 | 0.89 | RXRA (0.49) | RXRARXRBTP53TSHRCES2 | |
| Terephthalic Acid SCHEMBL11809850 | 0.86 | TSHR (0.52) | TP53TSHRKMT2AALDH1A1SMN1; SMN2 | |
| Terephthalic Acid SCHEMBL27843678 | 0.86 | TSHR (0.52) | TP53TSHRKMT2AALDH1A1SMN1; SMN2 | |
| Terephthalic Acid SCHEMBL29132843 | 0.86 | TSHR (0.52) | TP53TSHRKMT2AALDH1A1SMN1; SMN2 | |
| 4-Methylbenzoic Acid SCHEMBL5081494 | 0.82 | ALDH1A1 (0.68) | RXRARXRBTP53TSHRCES2 | |
| Paraben SCHEMBL4616664 | 0.82 | CA2 (0.64) | RXRARXRBTP53TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1666505-B1 | CATALYST COMPONENTS CATALYSTS FOR OLEFINIC POLYMERIZATION AND THE USE THEREOF | CHINA PETROLEUM & CHEMICAL (CN) | 2016-03-23 | — | — | EP | disclosed |
| US-7332455-B2 | Catalyst component and catalyst for olefin polymerization as well as use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2008-02-19 | — | — | US | disclosed |
| EP-1666505-A1 | CATALYST COMPONENTS CATALYSTS FOR OLEFINIC POLYMERIZATION AND THE USE THEREOF | China Petroleum & Chemical Corporation (CN) | 2006-06-07 | — | — | EP | disclosed |
| US-20050119427-A1 | Catalyst component and catalyst for olefin polymerization as well as use thereof | BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2005-06-02 | — | — | US | disclosed |