Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5089560 | 1.00 | CTSK (0.45) | CTSKITGB3ITGA2BTDP1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27464326 | 0.87 | L3MBTL1 (0.47) | ITGB3SMN1; SMN2PPARGPPARALMNA | |
| SCHEMBL5502754 | 0.86 | HPGD (0.52) | CTSKITGB3ITGA2BTDP1SMN1; SMN2 | |
| SCHEMBL3870705 | 0.86 | CTSK (0.48) | CTSKITGB3ITGA2BTDP1SMN1; SMN2 | |
| SCHEMBL5503388 | 0.86 | CTSK (0.48) | CTSKITGB3ITGA2BTDP1SMN1; SMN2 | |
| SCHEMBL10477426 | 0.86 | ITGB1 (0.44) | CTSKITGB3ITGA2BTDP1SMN1; SMN2 | |
| SCHEMBL10477428 | 0.86 | ITGB1 (0.44) | CTSKITGB3ITGA2BTDP1SMN1; SMN2 | |
| SCHEMBL6663760 | 0.86 | PPARA (0.44) | CTSKITGB3ITGA2BTDP1SMN1; SMN2 | |
| SCHEMBL5088784 | 0.85 | ALDH1A1 (0.52) | CTSKITGB3ITGA2BTDP1SMN1; SMN2 | |
| SCHEMBL2185240 | 0.84 | ITGB3 (0.58) | CTSKITGB3ITGA2BACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008101840-A1 | COMBINATION OF ERLOTINIB AND MEK-INHIBITORS FOR INHIBITING PROLIFERATION OF TUMOR CELLS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-28 | — | — | WO | disclosed |