SCHEMBL5086744

SCHEMBL5086744

CC1=CC(=C(c2ccccc2)c2ccccc2)C=C1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
HTT P42858 2/20 0.41
TDP1 Q9NUW8 4/20 0.38
HDAC6 Q9UBN7 1/20 0.38
LMNA P02545 3/20 0.35
MAPK1 P28482 3/20 0.35
HIF1A Q16665 3/20 0.35
ALDH1A1 P00352 3/20 0.35
CYP3A4 P08684 3/20 0.35
HPGD P15428 3/20 0.35
THRB P10828 2/20 0.35
HSD17B10 Q99714 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
TP53 P04637 2/20 0.35
ALOX15 P16050 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
ALOX12 P18054 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5084156 0.74 TDP1 (0.36) MEN1KMT2AHTTTDP1HDAC6
SCHEMBL2274381 0.74 TDP1 (0.39) MEN1KMT2AHTTTDP1HDAC6
SCHEMBL647841 0.69 TDP1 (0.40) MEN1KMT2AHTTTDP1HDAC6
SCHEMBL5083754 0.69 TDP1 (0.35) MEN1KMT2AHTTTDP1HDAC6
SCHEMBL8739454 0.68 CYP3A4 (0.63) MEN1KMT2AHTTTDP1HDAC6
SCHEMBL13020966 0.68 TDP1 (0.65) MEN1KMT2AHTTTDP1HDAC6
SCHEMBL15906345 0.67 NFKB1 (0.31) MEN1KMT2ALMNACES2CES1
SCHEMBL31382802 0.64 TDP1 (0.37) MEN1KMT2AHTTTDP1HDAC6
SCHEMBL9226914 0.63 CES1 (0.43) MEN1KMT2ATDP1LMNAMAPK1
SCHEMBL11327650 0.61 CES2 (0.54) MEN1KMT2ATDP1HDAC6MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1498178-B1 Transition metal complex and process for producing the same SUMITOMO CHEMICAL CO (JP) 2008-06-11 EP disclosed
EP-1498178-A2 Transition metal complex, process for producing the same, olefin polymerization catalyst containing the transition metal complex and process for producing olefin polymers Sumitomo Chemical Company, Limited (JP) 2005-01-19 EP disclosed
EP-0842939-B1 OLEFIN POLYMERIZATION CATALYST CONTAINING A TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL CO (JP) 2004-10-06 EP disclosed
EP-1169356-B1 POLYOLEFIN PRODUCTION ATOFINA RES (BE) 2004-07-14 EP disclosed
US-6515086-B1 A process for preparing polyolefins having a monomer length of up to C10, which comprises first contacting: (1) a metallocene catalyst component for the preparation of a polyolefin which comprises an isotactic polyolefin or FINA RESEARCH, S.A. (BE) 2003-02-04 US disclosed
CN-1346373-A Polyolefin production ATO FINA RES S A (BE) 2002-04-24 CN disclosed
EP-1169356-A1 POLYOLEFIN PRODUCTION ATOFINA Research (BE) 2002-01-09 EP disclosed
US-6329478-B1 SOLUBILITY IN SATURATED HYDROCARBON SOLVENTS SUMITMO CHEMICAL COMPANY, LIMITED 2001-12-11 US disclosed
WO-2000049029-A1 POLYOLEFIN PRODUCTION FINA RESEARCH S.A. (BE) 2000-08-24 WO disclosed
WO-2000049056-A1 POLYOLEFIN PRODUCTION ATOFINA RESEARCH (BE) 2000-08-24 WO disclosed
EP-0842939-A1 TRANSITION METAL COMPLEX, PROCESS FOR THE PREPARATION THEREOF, POLYMERIZATION CATALYST FOR OLEFINS CONTAINING THE COMPLEX, AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-05-20 EP disclosed