SCHEMBL5090072

SCHEMBL5090072

Cc1cc(Br)c(O)c([Si](C)(C)C(C)(C)C)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 4/20 0.39
ALDH1A1 P00352 3/20 0.39
TSHR P16473 3/20 0.39
ALOX15 P16050 2/20 0.39
ALOX12 P18054 2/20 0.39
CYP3A4 P08684 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
HSD17B10 Q99714 2/20 0.39
HPGD P15428 1/20 0.39
CASP1 P29466 1/20 0.39
RECQL P46063 1/20 0.39
CA2 P00918 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
POLB P06746 1/20 0.36
TYR P14679 1/20 0.36
NQO2 P16083 1/20 0.35
CA1 P00915 1/20 0.34
CA4 P22748 1/20 0.34
CA6 P23280 1/20 0.34
CHEK1 O14757 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5090508 0.80 NQO2 (0.39) HIF1AALDH1A1TSHRALOX15ALOX12
SCHEMBL5084191 0.75 ACHE (0.39) ALDH1A1TSHRALOX15ALOX12HSD17B10
SCHEMBL1502445 0.72 CYP3A4 (0.58) HIF1AALDH1A1TSHRALOX15ALOX12
SCHEMBL5086998 0.72 CA2 (0.34) HIF1AALDH1A1TSHRALOX15ALOX12
Methane SCHEMBL21814228 0.70 CYP3A4 (0.55) HIF1AALDH1A1TSHRALOX15ALOX12
SCHEMBL1628174 0.68 SMN1; SMN2 (0.71) HIF1AALDH1A1TSHRALOX15ALOX12
SCHEMBL4304730 0.68 NR1H2 (0.39) TSHRCYP3A4HSD17B10HPGDCA2
SCHEMBL5089917 0.67 MEN1 (0.43) ALDH1A1CYP3A4HPGDSMN1; SMN2CYP2C19
SCHEMBL11418582 0.66 SELL (0.65) HIF1AALDH1A1TSHRALOX15ALOX12
SCHEMBL2044956 0.66 ALDH1A1 (0.52) HIF1AALDH1A1TSHRALOX15ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1498178-B1 Transition metal complex and process for producing the same SUMITOMO CHEMICAL CO (JP) 2008-06-11 EP disclosed
EP-1498178-A2 Transition metal complex, process for producing the same, olefin polymerization catalyst containing the transition metal complex and process for producing olefin polymers Sumitomo Chemical Company, Limited (JP) 2005-01-19 EP disclosed
CN-1185236-C Transition metal compound, its producing process olefine polymerization catalyst containing the same transition metal compound and process for producing olefine polymer SUMITOMO CHEMICAL CO (JP) 2005-01-19 CN disclosed
EP-0842939-B1 OLEFIN POLYMERIZATION CATALYST CONTAINING A TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL CO (JP) 2004-10-06 EP disclosed
US-6329478-B1 SOLUBILITY IN SATURATED HYDROCARBON SOLVENTS SUMITMO CHEMICAL COMPANY, LIMITED 2001-12-11 US disclosed
CN-1310183-A Transition metal compound, its producing process olefine polymerization catalyst containing the same transition metal compound and process for producing olefine polymer SUMITOMO CHEMICAL CO (JP) 2001-08-29 CN disclosed
CN-1068884-C Transition metal complex, process for producing the same, olefin polymerization catalyst containing the transition metal complex, and process for producing olefin polymer SUMITOMO CHEM IND (JP) 2001-07-25 CN disclosed
CN-1193323-A Transition metal complex, process for producing the same, olefin polymerization catalyst containing the transition metal complex, and process for producing olefin polymer SUMITOMO CHEM IND (JP) 1998-09-16 CN disclosed
EP-0842939-A1 TRANSITION METAL COMPLEX, PROCESS FOR THE PREPARATION THEREOF, POLYMERIZATION CATALYST FOR OLEFINS CONTAINING THE COMPLEX, AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-05-20 EP disclosed