Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 11/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.77 |
| ▸ | NPC1 | O15118 | 5/20 | 0.77 |
| ▸ | RAB9A | P51151 | 4/20 | 0.77 |
| ▸ | POLB | P06746 | 3/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.76 |
| ▸ | HTT | P42858 | 2/20 | 0.76 |
| ▸ | USP2 | O75604 | 1/20 | 0.76 |
| ▸ | TP53 | P04637 | 1/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | BRAF | P15056 | 1/20 | 0.69 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.62 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598296 | 0.90 | ALOX12 (1.00) | ALOX12KDM4ENPC1RAB9APOLB | |
| SCHEMBL17223785 | 0.88 | ALOX12 (0.81) | ALOX12KDM4ENPC1RAB9APOLB | |
| SCHEMBL609251 | 0.87 | ALOX12 (1.00) | ALOX12KDM4ENPC1RAB9APOLB | |
| SCHEMBL17223781 | 0.86 | KDM4E (1.00) | ALOX12KDM4ENPC1RAB9APOLB | |
| SCHEMBL1811278 | 0.85 | ADAMTS5 (0.79) | ALOX12KDM4ENPC1RAB9APOLB | |
| SCHEMBL608085 | 0.85 | KDM4E (0.79) | ALOX12KDM4ENPC1RAB9APOLB | |
| SCHEMBL5095826 | 0.85 | NPC1 (0.83) | ALOX12KDM4ENPC1RAB9APOLB | |
| SCHEMBL13236170 | 0.85 | MEN1 (0.76) | ALOX12KDM4ENPC1RAB9APOLB | |
| SCHEMBL5090799 | 0.84 | ADAMTS5 (0.74) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL610979 | 0.84 | HSP90AA1 (1.00) | ALOX12KDM4ENPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269213-A1 | 8-Hydroxyquinoline compounds and methods thereof | WYETH (US) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269213-A1 | 8-Hydroxyquinoline compounds and methods thereof | MMP8, MMP26, MMP9 | ALOX12 594/4885KDM4E 4164/4885NPC1 2196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.