Sugi Predict

Sugi Predict / Compounds / SCHEMBL509379

SCHEMBL509379

SCHEMBL509379

COc1ccc(C#N)c(C)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AR P10275 6/20 0.50
▸ PGR P06401 2/20 0.47
▸ MEN1 O00255 2/20 0.46
▸ KMT2A Q03164 2/20 0.46
▸ GLA P06280 2/20 0.46
▸ MAOB P27338 1/20 0.46
▸ GAA P10253 2/20 0.46
▸ POLB P06746 2/20 0.46
▸ L3MBTL1 Q9Y468 2/20 0.45
▸ PPARG P37231 1/20 0.45
▸ NCOA2 Q15596 1/20 0.45
▸ NCOA1 Q15788 1/20 0.45
▸ NPSR1 Q6W5P4 1/20 0.45
▸ RXFP1 Q9HBX9 1/20 0.45
▸ NCOA3 Q9Y6Q9 1/20 0.45
▸ TSHR P16473 2/20 0.45
▸ KDM4E B2RXH2 3/20 0.45
▸ ALDH1A1 P00352 3/20 0.45
▸ NQO1 P15559 1/20 0.44
▸ MRGPRX4 Q96LA9 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4428480 0.85 AR (0.62) ARPGRMEN1KMT2AMAOB
SCHEMBL509547 0.83 L3MBTL1 (0.49) ARPGRMEN1KMT2AGLA
SCHEMBL9560109 0.83 MAOB (0.57) ARPGRMEN1KMT2AGLA
SCHEMBL25680960 0.82 AR (0.44) ARPGRMAOBTSHRKDM4E
SCHEMBL6110658 0.80 AR (0.43) ARPGRMAOBTSHRKDM4E
SCHEMBL30730992 0.79 ALDH1A1 (0.63) ARPGRMEN1KMT2AGLA
SCHEMBL15201858 0.79 AR (0.47) ARPGRMEN1KMT2AGLA
SCHEMBL1762094 0.79 ALDH1A1 (0.63) ARPGRMEN1KMT2AGLA
SCHEMBL1608900 0.79 AR (0.69) ARPGRGAAPOLBKDM4E
SCHEMBL2704176 0.79 ACACB (0.43) GAAL3MBTL1KDM4EALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025065102-A1 PHENYLTHIONE-2,3-DIHYDRO-1H-PYRROLIZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS H2S-RELEASING KETOROLAC ANALOGUES ANTIBE THERAPEUTICS INC. (CA) 2025-04-03 — — WO disclosed
US-20230131252-A1 PHTHALAZINONE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF SHANGHAI JEYOU PHARMACEUTICAL CO., LTD. (CN) 2023-04-27 — — US disclosed
US-10683269-B2 2-cyanoisoindoline derivatives for treating cancer MISSION THERAPEUTICS LIMITED (GB) 2020-06-16 — — US disclosed
WO-2017158388-A1 2-CYANOISOINDOLINE DERIVATIVES FOR TREATING CANCER MISSION THERAPEUTICS LIMITED (GB) 2017-09-21 — — WO disclosed
US-9695166-B2 Pyrazolopyridine pyrazolopyrimidine and related compounds GLOBAL BLOOD THERAPEUTICS, INC. (US) 2017-07-04 — — US disclosed
US-9505749-B2 Quinazolinone compounds and derivatives thereof AMGEN INC. (US) 2016-11-29 — — US disclosed
WO-2015171527-A1 PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS GLOBAL BLOOD THERAPEUTICS, INC. (US) 2015-11-12 — — WO disclosed
US-20150315198-A1 PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS GLOBAL BLOOD THERAPEUTICS, INC. (US) 2015-11-05 — — US disclosed
EP-2086963-B1 HEPATITIS C VIRUS INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2015-09-16 — — EP disclosed
EP-2086963-B1 HEPATITIS C VIRUS INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2015-09-16 — — EP disclosed
WO-2008060927-A2 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2008-05-22 — — WO disclosed
WO-2008060927-A2 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2008-05-22 — — WO disclosed
US-20080085919-A1 1H-Pyrazoles Useful In Therapy BRADLEY PAUL A 2008-04-10 — — US disclosed
US-7309712-B2 1H-pyrazoles useful in therapy PFIZER LIMITED (GB) 2007-12-18 — — US disclosed
WO-2007054770-A2 PYRAZOLE DERIVATIVES AND THEIR MEDICAL USE PFIZER LIMITED (GB) 2007-05-18 — — WO disclosed
US-20070105909-A1 Compounds useful in therapy PFIZER INC. 2007-05-10 — — US disclosed
US-20060241125-A1 Compounds useful in therapy BRADLEY PAUL A 2006-10-26 — — US disclosed
US-5354869-A Fluorescent dyes RIEDEL-DE HAEN AKTIENGESELLSCHAFT (DE) 1994-10-11 — — US disclosed
EP-0426717-A1 OPTICAL MEMORY. RIEDEL DE HAEN AG (DE) 1991-05-15 — — EP disclosed
WO-1990001480-A1 OPTICAL MEMORY RIEDEL-DE HAEN AKTIENGESELLSCHAFT (DE) 1990-02-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150315198-A1 PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS TPMT, DPYD, XDH AR 4282/4885PGR 3344/4885MEN1 2247/4885
US-20070105909-A1 Compounds useful in therapy GNRHR, OPRK1, CBR3 AR 468/4885PGR 155/4885MEN1 989/4885
US-20080085919-A1 1H-Pyrazoles Useful In Therapy CBR3, GNRHR, RXFP3 AR 563/4885PGR 87/4885MEN1 1373/4885
US-10683269-B2 2-cyanoisoindoline derivatives for treating cancer USP7, USP47, USP2 AR 4718/4885PGR 4365/4885MEN1 2624/4885
US-20230131252-A1 PHTHALAZINONE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF CYP17A1, AR, NR5A1 AR 2/4885PGR 131/4885MEN1 425/4885
US-20060241125-A1 Compounds useful in therapy CBR3, GPER1, CBR1 AR 387/4885PGR 57/4885MEN1 2554/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.