Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 17/20 | 0.43 |
| ▸ | CTSL | P07711 | 9/20 | 0.43 |
| ▸ | CTSS | P25774 | 9/20 | 0.43 |
| ▸ | CTSB | P07858 | 5/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5106030 | 0.91 | CTSK (0.41) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7432025 | 0.90 | ALDH1A1 (0.45) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5092584 | 0.87 | CTSK (0.47) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4767334 | 0.87 | ATM (0.44) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5099617 | 0.86 | CTSK (0.42) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4686326 | 0.84 | CTSK (0.60) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5096573 | 0.83 | EPHX2 (0.42) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7427117 | 0.83 | MEN1 (0.52) | MEN1KMT2A | |
| SCHEMBL4766701 | 0.83 | MEN1 (0.43) | CTSKCTSLCTSSCTSBMEN1 | |
| SCHEMBL7434825 | 0.83 | KMT2A (0.45) | CTSKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7405209-B2 | e.g. 2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-3-oxo-azepan-4-ylcarbamoyl}carbamic acid benzyl ester; protease inhibitors like cathepsin K; osteoporosis, osteo- and rheumatoid arthritis and periodontal disease; inhibiting excessive cartilage or matrix degradation | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-29 | — | — | US | disclosed |
| US-20050256104-A1 | substituted 1,1,4-1l6-trioxo[1,2]thiazepan-4-ylamide-derived protease inhibitors which inhibit the likes of cathepsin K; treating osteoporosis, osteo- and rheumatoid arthritis and periodontal disease; inhibiting excessive cartilage or matrix degradation | SMITHKLINE BEECHAM CORPORATION | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256104-A1 | substituted 1,1,4-1l6-trioxo[1,2]thiazepan-4-ylamide-derived protease inhibitors which inhibit the likes of cathepsin K; treating osteoporosis, osteo- and rheumatoid arthritis and periodontal disease; inhibiting excessive cartilage or matrix degradation | CTSK, CTSZ, CTSE | CTSK 1/4885CTSL 19/4885CTSS 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.