SCHEMBL509729

SCHEMBL509729

CN(CCCC1CCC2OC2C1)C(=O)OC(C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 5/20 0.36
NR1H2 P55055 1/20 0.33
FPR3 P25089 1/20 0.31
FPR2 P25090 1/20 0.31
FAAH O00519 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
PKM P14618 1/20 0.30
KDM5A P29375 1/20 0.30
KDM7A Q6ZMT4 1/20 0.30
KDM4C Q9H3R0 1/20 0.30
PHF8 Q9UPP1 1/20 0.30
KDM2A Q9Y2K7 1/20 0.30
HSD11B1 P28845 1/20 0.30
HTR2C P28335 1/20 0.30
SLC6A4 P31645 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL509477 0.88 CPB2 (0.37) NR1H2
SCHEMBL27123113 0.77 ITGB3 (0.37) GPR119FAAH
SCHEMBL28868811 0.76 GPR119 (0.44) GPR119FAAHKMT2APKMHSD11B1
SCHEMBL13650556 0.76 ALDH1A1 (0.37) GPR119FPR3FPR2KMT2AHTR2C
SCHEMBL29726619 0.75 TDP1 (0.46) MEN1KMT2ATDP1
SCHEMBL6018866 0.75 LSS (0.35) GPR119NR1H2FPR3FPR2KDM5A
SCHEMBL6018862 0.75 LSS (0.35) GPR119NR1H2FPR3FPR2KDM5A
SCHEMBL4810634 0.74 ALDH1A1 (0.38) FPR3FPR2
SCHEMBL4818666 0.74 ALDH1A1 (0.38) FPR3FPR2
SCHEMBL4810639 0.74 ALDH1A1 (0.38) FPR3FPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220218713-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2022-07-14 US disclosed
US-20210113571-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2021-04-22 US disclosed
US-20200281933-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2020-09-10 US disclosed
US-20200030335-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2020-01-30 US disclosed
US-20190175603-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2019-06-13 US disclosed
US-20180303842-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2018-10-25 US disclosed
US-20170266194-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2017-09-21 US disclosed
EP-2380874-B1 Pleuromutilin derivatives for the treatment of diseases mediated by microbes NABRIVA THERAPEUTICS AG (AT) 2016-12-28 EP disclosed
US-20140256731-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES NABRIVA THERAPEUTICS AG (AT) 2014-09-11 US disclosed
US-20130040954-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2013-02-14 US disclosed
US-8153689-B2 Pleuromutilin derivatives for the treatment of diseases mediated by microbes NABRIVA THERAPEUTICS AG (AT) 2012-04-10 US disclosed
US-20120029072-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES NABRIVA THERAPEUTICS AG 2012-02-02 US disclosed
US-8071643-B2 Pleuromutilin derivatives for the treatment of diseases mediated by microbes NABRIVA THERAPEUTICS AG (AT) 2011-12-06 US disclosed
EP-2380874-A2 Pleuromutilin derivatives for the treatment of diseases mediated by microbes Nabriva Therapeutics AG (AT) 2011-10-26 EP disclosed
EP-2137143-B1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES NABRIVA THERAPEUTICS AG (AT) 2011-09-07 EP disclosed
US-20100035987-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES NABRIVA THERAPEUTICS AG (AT) 2010-02-11 US disclosed
EP-2137143-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES Nabriva Therapeutics AG (AT) 2009-12-30 EP disclosed
WO-2008113089-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES NABRIVA THERAPEUTICS AG (AT) 2008-09-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200281933-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 335/4885NR1H2 873/4885FPR3 783/4885
US-20140256731-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 401/4885NR1H2 719/4885FPR3 722/4885
US-20220218713-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 383/4885NR1H2 909/4885FPR3 856/4885
US-20130040954-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 401/4885NR1H2 719/4885FPR3 722/4885
US-20190175603-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 335/4885NR1H2 873/4885FPR3 783/4885
US-20170266194-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HRH4, HRH2, CHRM1 GPR119 673/4885NR1H2 1541/4885FPR3 236/4885
US-20100035987-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, FABP6, ALPI GPR119 260/4885NR1H2 571/4885FPR3 1037/4885
US-20200030335-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HRH4, HRH2, CHRM1 GPR119 673/4885NR1H2 1541/4885FPR3 236/4885
US-20210113571-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 383/4885NR1H2 909/4885FPR3 856/4885
US-20180303842-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 335/4885NR1H2 873/4885FPR3 783/4885
US-20120029072-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, FABP6, PLEC GPR119 242/4885NR1H2 541/4885FPR3 868/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.