Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUCNR1 | Q9BXA5 | 3/20 | 0.50 |
| ▸ | RXRA | P19793 | 2/20 | 0.47 |
| ▸ | RXRB | P28702 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.44 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355633 | 0.87 | SHMT1 (0.41) | SUCNR1PTGDR2SHMT1SHMT2KDM4E | |
| SCHEMBL19512763 | 0.86 | RXRA (0.49) | RXRARXRBPTGS1RXRGMEN1 | |
| SCHEMBL19512828 | 0.86 | PTGS1 (0.61) | SUCNR1RXRARXRBPTGS1RXRG | |
| SCHEMBL3632865 | 0.86 | KEAP1 (0.50) | SUCNR1PTGDR2ABCB11PTGS2ABCB1 | |
| SCHEMBL508733 | 0.83 | RXRA (0.49) | RXRARXRBPTGS1PTGDR2RXRG | |
| SCHEMBL2347456 | 0.83 | SUCNR1 (0.50) | SUCNR1PTGS1PTGDR2DGAT1KDM4E | |
| SCHEMBL5535142 | 0.83 | ACLY (0.47) | SUCNR1SHMT1SHMT2KDM4EALDH1A1 | |
| SCHEMBL2347293 | 0.82 | RXRA (0.51) | SUCNR1RXRARXRBPTGS1PTGDR2 | |
| SCHEMBL2354381 | 0.81 | RXRA (0.51) | SUCNR1RXRARXRBPTGS1PTGDR2 | |
| SCHEMBL3840860 | 0.81 | PTGS1 (0.51) | RXRARXRBPTGS1RXRGPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9307767-B2 | Herbicidally and insecticidally active thiazolopyridinones | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-04-12 | — | — | US | disclosed |
| EP-2831084-B1 | HERBICIDAL AND INSECTICIDAL THIAZOLOPYRIDINONES | BAYER IP GMBH (DE) | 2016-03-23 | — | — | EP | disclosed |
| US-9278925-B2 | Substituted 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-03-08 | — | — | US | disclosed |
| US-9212140-B2 | (5s,8s)-3-(4′-chlor-3′-fluor-4-methlybiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5] dec-3-en-2-one (compound A) for treatment | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-15 | — | — | US | disclosed |
| US-9000026-B2 | Substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones for therapy | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-04-07 | — | — | US | disclosed |
| US-20150045217-A1 | Herbicidally and Insecticidally Active Thiazolopyridinones | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2015-02-12 | — | — | US | disclosed |
| EP-2831084-A1 | HERBICIDALLY AND INSECTICIDALLY ACTIVE THIAZOLOPYRIDINONES | Bayer Intellectual Property GmbH (DE) | 2015-02-04 | — | — | EP | disclosed |
| US-8946124-B2 | Substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones for therapy and halogen-substituted spirocyclic ketoenols | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| US-20140275199-A1 | SUBSTITUTED 3-(BIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-09-18 | — | — | US | disclosed |
| EP-2739607-A1 | SUBSTITUTED 3-(BIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE | Bayer Intellectual Property GmbH (DE) | 2014-06-11 | — | — | EP | disclosed |
| EP-2188264-A2 | PYRIDAZINONE COMPOUND AND HERBICIDE CONTAINING THE SAME | Sumitomo Chemical Company, Limited (JP) | 2010-05-26 | — | — | EP | disclosed |
| US-20090298828-A1 | Alkoxyalkyl-Substituted Cyclic Keto-Enols | BAYER CROPSCIENCE AG (DE) | 2009-12-03 | — | — | US | disclosed |
| CN-101495448-A | alkoxyalkyl-substituted cyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2009-07-29 | — | — | CN | disclosed |
| WO-2009035150-A2 | 4-PHENYL-5-HYDROXY-3(2H)-PYRIDAZINONE DERIVATIVES AS HERBICIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-03-19 | — | — | WO | disclosed |
| EP-1303505-B1 | PHENYL-SUBSTITUTED 5,6-DIHYDROPYRONE DERIVATIVES FOR USE AS PESTICIDES AND HERBICIDES | BAYER CROPSCIENCE AG (DE) | 2008-09-03 | — | — | EP | disclosed |
| CN-1229368-C | Phenyl-substituted 5,6-dihydropyrone derivatives for use as pesticides and herbicides | BAYER CROP SCIENCE AG (DE) | 2005-11-30 | — | — | CN | disclosed |
| US-6906007-B2 | Phenyl-substituted 5,6-dihydropyrone derivatives for use as pesticides and herbicides | BAYER CROPSCIENCE AG (DE) | 2005-06-14 | — | — | US | disclosed |
| US-20040102516-A1 | Phenyl-substituted 5,6-dihydrophyne derivatives for use as pesticides and herbicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2004-05-27 | — | — | US | disclosed |
| EP-1303505-A1 | PHENYL-SUBSTITUTED 5,6-DIHYDROPYRONE DERIVATIVES FOR USE AS PESTICIDES AND HERBICIDES | Bayer Aktiengesellschaft (DE) | 2003-04-23 | — | — | EP | disclosed |
| WO-2001098288-A1 | PHENYL-SUBSTITUTED 5,6-DIHYDROPYRONE DERIVATIVES FOR USE AS PESTICIDES AND HERBICIDES | BAYER CROPSCIENCE AG (DE) | 2001-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275199-A1 | SUBSTITUTED 3-(BIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE | MALT1, UGT1A3, BMI1 | SUCNR1 2778/4885RXRA 84/4885RXRB 58/4885 |
| US-20090298828-A1 | Alkoxyalkyl-Substituted Cyclic Keto-Enols | DDT, AKR1D1, EBP | SUCNR1 3739/4885RXRA 2372/4885RXRB 1984/4885 |
| US-20040102516-A1 | Phenyl-substituted 5,6-dihydrophyne derivatives for use as pesticides and herbicides | DDT, CYP1B1, CYP1A1 | SUCNR1 2375/4885RXRA 2221/4885RXRB 1742/4885 |
| US-20150045217-A1 | Herbicidally and Insecticidally Active Thiazolopyridinones | CBR3, DDT, CBR1 | SUCNR1 2132/4885RXRA 1647/4885RXRB 1602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.