Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 13/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 13/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27951170 | 0.87 | ALDH1A1 (0.53) | ALDH1A1GAAUSP2PKMHPGD | |
| SCHEMBL12095399 | 0.87 | ALDH1A1 (0.60) | ALDH1A1GAAUSP2PKMHPGD | |
| Hydrochloric Acid SCHEMBL12100554 | 0.85 | GAA (0.58) | ALDH1A1GAAUSP2PKMHPGD | |
| SCHEMBL31368762 | 0.84 | AKR1C3 (0.55) | GAAALOX15HSD17B10HIF1AAKR1C3 | |
| SCHEMBL26170478 | 0.84 | AKR1C3 (0.55) | GAAALOX15HSD17B10HIF1AAKR1C3 | |
| SCHEMBL11193984 | 0.81 | AKR1C3 (0.53) | AKR1C3AKR1C2AKR1C1PTGS1AKR1B10 | |
| SCHEMBL272899 | 0.80 | ALDH1A1 (0.70) | ALDH1A1GAAUSP2PKMHPGD | |
| SCHEMBL2795502 | 0.80 | AKR1C3 (0.61) | AKR1C3AKR1C2AKR1C1PTGS1AKR1B10 | |
| SCHEMBL1556908 | 0.80 | AKR1C3 (0.51) | AKR1C3AKR1C2AKR1C1PTGS1AKR1B10 | |
| SCHEMBL298386 | 0.79 | TSHR (0.67) | ALDH1A1GAAHTTAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348017-B2 | Dithiazole compounds, matrix metalloprotease inhibitors and external preparations for the skin | SHISEIDO CO., LTD. (JP) | 2008-03-25 | — | — | US | disclosed |
| US-20040236111-A1 | Dithiazole compounds, matrix metalloprotease inhibitors and external preparations for the skin | SHISEIDO CO., LTD. (JP) | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236111-A1 | Dithiazole compounds, matrix metalloprotease inhibitors and external preparations for the skin | MMP1, MMP2, MMP3 | ALDH1A1 253/4885GAA 785/4885USP2 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.