Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3482961 | 0.80 | ALDH1A1 (0.40) | HSD11B1POLBLMNAKMT2AALDH1A1 | |
| SCHEMBL9405550 | 0.79 | GAA (0.30) | — | |
| SCHEMBL4297335 | 0.77 | CA1 (0.33) | POLBMAPK1TSHRKMT2AALDH1A1 | |
| SCHEMBL7998472 | 0.74 | KDM4E (0.34) | KMT2A | |
| SCHEMBL28463231 | 0.73 | L3MBTL1 (0.33) | POLBLMNAMAPTTSHRALDH1A1 | |
| SCHEMBL28404636 | 0.72 | KDM4E (0.33) | — | |
| SCHEMBL28519204 | 0.71 | L3MBTL1 (0.32) | — | |
| Sulfuric Acid SCHEMBL11764713 | 0.71 | HSD11B1 (0.44) | HSD11B1POLBKMT2A | |
| SCHEMBL262312 | 0.69 | — | — | |
| SCHEMBL577052 | 0.69 | CHRNA7 (0.48) | HSD11B1MAPTKMT2AALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120027815-A1 | USE OF PLASMA MEMBRANE CALCIUM ATPASE (PMCA) INHIBITORS TO INHIBIT SPERM MOBILITY | LG ELECTRONICS INC. (KR) | 2012-02-02 | — | — | US | disclosed |
| US-20060276529-A1 | Use of plasma membrane calcium atpase (pmca) inhibitors for inhibiting sperm mobility | NEYSES LUDWIG | 2006-12-07 | — | — | US | disclosed |