Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 8/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | PRKACG | P22612 | 1/20 | 0.42 |
| ▸ | PRKACB | P22694 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14507422 | 0.80 | IKBKB (0.45) | IKBKBLIMK1BTKCHUKPRKACA | |
| SCHEMBL4211782 | 0.80 | KDR (0.43) | IKBKBLIMK1BTKCHUKPRKACA | |
| SCHEMBL15943484 | 0.80 | IKBKB (0.50) | IKBKBLIMK1BTKCHUKPRKACA | |
| SCHEMBL5104631 | 0.79 | PKM (0.52) | POLBHSD17B10MEN1KMT2AALOX15 | |
| SCHEMBL102004 | 0.79 | ALDH1A1 (0.40) | GAAPOLBMEN1KMT2AALOX15 | |
| SCHEMBL12917929 | 0.78 | IKBKB (0.40) | IKBKBLIMK1BTKCHUKPRKACA | |
| SCHEMBL27398499 | 0.78 | F10 (0.41) | IKBKBLIMK1BTKCHUKPRKACA | |
| SCHEMBL3057931 | 0.77 | PKM (0.37) | GAAHSD17B10MEN1KMT2AALOX15 | |
| SCHEMBL22066870 | 0.77 | IKBKB (0.40) | IKBKBLIMK1BTKCHUKPRKACA | |
| SCHEMBL18719429 | 0.76 | POLB (0.38) | POLBHSD17B10MEN1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9044389-B2 | Isoxazoline derivatives as pesticides | NOVARTIS TIERGESUNDHEIT AG (CH) | 2015-06-02 | — | — | US | disclosed |
| US-20140120147-A1 | ISOXAZOLINE DERIVATIVES AS PESTICIDES | NOVARTIS AG (CH) | 2014-05-01 | — | — | US | disclosed |
| US-8653116-B2 | Isoxazoline derivatives as pesticides | NOVARTIS AG (CH) | 2014-02-18 | — | — | US | disclosed |
| US-20130131053-A1 | ISOXAZOLINE DERIVATIVES AS PESTICIDES | NOVARTIS TIERGESUNDHEIT AG (CH) | 2013-05-23 | — | — | US | disclosed |
| US-8383659-B2 | Isoxazoline derivatives as pesticides | NOVARTIS AG (CH) | 2013-02-26 | — | — | US | disclosed |
| US-20110245239-A1 | ORGANIC COMPOUNDS | ELANCO TIERGESUNDHEIT AG (CH) | 2011-10-06 | — | — | US | disclosed |
| WO-2001066534-A2 | CYCLIC AND BICYCLIC DIAMINO HISTAMINE-3 RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2001-09-13 | — | — | WO | disclosed |
| WO-1998042323-A1 | STABILIZED UREASE INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-10-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131053-A1 | ISOXAZOLINE DERIVATIVES AS PESTICIDES | CYP3A7, ACHE, CYP4X1 | IKBKB 2971/4885LIMK1 3968/4885BTK 408/4885 |
| US-20140120147-A1 | ISOXAZOLINE DERIVATIVES AS PESTICIDES | CYP3A7, ACHE, CYP4X1 | IKBKB 2971/4885LIMK1 3968/4885BTK 408/4885 |
| US-20110245239-A1 | ORGANIC COMPOUNDS | ACHE, VDAC1, VDAC2 | IKBKB 3497/4885LIMK1 3096/4885BTK 3055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.