Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5114606 | 0.83 | TRPM8 (0.46) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| SCHEMBL11215068 | 0.83 | TRPM8 (0.42) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| SCHEMBL7766491 | 0.81 | TRPM8 (0.40) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| SCHEMBL21380098 | 0.76 | TRPM8 (0.48) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| SCHEMBL1862576 | 0.76 | TRPM8 (0.48) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| SCHEMBL10713470 | 0.73 | TRPM8 (0.46) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| SCHEMBL30604482 | 0.73 | TRPM8 (0.62) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| SCHEMBL25831066 | 0.73 | TRPM8 (0.53) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| SCHEMBL21380222 | 0.72 | EPHX1 (0.43) | TRPM8TRPA1EPHX1KCNA5CYP19A1 | |
| SCHEMBL5501055 | 0.71 | OPRM1 (0.47) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468380-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-12-23 | — | — | US | disclosed |
| US-20070004764-A1 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-01-04 | — | — | US | disclosed |
| US-7109219-B2 | Nitrogen-containing aromatic derivatives | EISAI CO., LTD. (JP) | 2006-09-19 | — | — | US | disclosed |
| US-20060004029-A1 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-01-05 | — | — | US | disclosed |
| US-20050187236-A1 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-08-25 | — | — | US | disclosed |
| EP-1522540-A1 | AZAARENE DERIVATIVES | Eisai Co., Ltd. (JP) | 2005-04-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004029-A1 | Nitrogen-containing aromatic derivatives | NR0B2, NR0B1, NR4A1 | TRPM8 2187/4885TRPA1 1234/4885EPHX1 2595/4885 |
| US-20050187236-A1 | Nitrogen-containing aromatic derivatives | NR0B2, NR0B1, NR4A1 | TRPM8 2187/4885TRPA1 1234/4885EPHX1 2595/4885 |
| US-20070004764-A1 | Nitrogen-containing aromatic derivatives | NR0B2, NR0B1, NR4A1 | TRPM8 2187/4885TRPA1 1234/4885EPHX1 2595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.