Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 13/20 | 0.56 |
| ▸ | TAS2R14 | Q9NYV8 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5623567 | 0.87 | CXCR3 (0.55) | CXCR3TAS2R14MEN1KMT2ATP53 | |
| SCHEMBL5117436 | 0.79 | TAS2R14 (0.74) | CXCR3TAS2R14MEN1KMT2APOLB | |
| SCHEMBL5115952 | 0.79 | TAS2R14 (0.60) | CXCR3TAS2R14MEN1KMT2APOLB | |
| SCHEMBL5116615 | 0.75 | TAS2R14 (0.76) | CXCR3TAS2R14MEN1KMT2A | |
| SCHEMBL1170300 | 0.74 | CXCR3 (0.85) | CXCR3TAS2R14MEN1KMT2ATP53 | |
| SCHEMBL5116368 | 0.74 | PSEN1 (0.53) | CXCR3TAS2R14MEN1KMT2ATP53 | |
| SCHEMBL5116372 | 0.74 | PSEN1 (0.53) | CXCR3TAS2R14MEN1KMT2ATP53 | |
| SCHEMBL9367212 | 0.74 | TSHR (0.54) | KMT2APOLB | |
| SCHEMBL1169373 | 0.73 | CXCR3 (0.67) | CXCR3TAS2R14MEN1KMT2ATP53 | |
| SCHEMBL1168758 | 0.73 | TAS2R14 (1.00) | CXCR3TAS2R14MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345095-B2 | Sulfonamide compounds for the treatment of neurodegenerative disorders | PFIZER INC (US) | 2008-03-18 | — | — | US | disclosed |