Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.58 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | HTR1D | P28221 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8578417 | 0.86 | AKR1C2 (0.55) | AKR1C2MTNR1AMTNR1BALDH1A1KDM4E | |
| SCHEMBL11788974 | 0.81 | RAD52 (0.50) | ALDH1A1KDM4EMAPTHSD17B10HTR1D | |
| SCHEMBL11488805 | 0.80 | HTR6 (0.58) | AKR1C2MTNR1AMTNR1BALDH1A1KDM4E | |
| SCHEMBL5272319 | 0.78 | AKR1C2 (0.55) | AKR1C2MTNR1AMTNR1BALDH1A1KDM4E | |
| SCHEMBL8796526 | 0.77 | AKR1C2 (0.48) | AKR1C2MTNR1AMTNR1BALDH1A1KDM4E | |
| SCHEMBL1434196 | 0.77 | ALDH1A1 (0.67) | AKR1C2MTNR1AMTNR1BALDH1A1KDM4E | |
| SCHEMBL9267967 | 0.76 | HTR1D (0.62) | AKR1C2MTNR1AMTNR1BALDH1A1KDM4E | |
| SCHEMBL5110673 | 0.75 | ALDH1A1 (0.61) | AKR1C2MTNR1AMTNR1BALDH1A1KDM4E | |
| SCHEMBL16494935 | 0.75 | AKR1C2 (0.51) | AKR1C2MTNR1AMTNR1BALDH1A1KDM4E | |
| SCHEMBL852717 | 0.74 | AKR1C2 (0.76) | AKR1C2MTNR1AMTNR1BALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332516-B2 | Geminally di-substituted NSAID derivatives as Aβ42 lowering agents | MERCK + CO., INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-7332516-B2 | Geminally di-substituted NSAID derivatives as Aβ42 lowering agents | MERCK + CO., INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-7332516-B2 | Geminally di-substituted NSAID derivatives as Aβ42 lowering agents | MERCK + CO., INC. (US) | 2008-02-19 | — | — | US | disclosed |
| EP-1587798-A4 | GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS | MERCK & CO INC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20060063937-A1 | Geminallyl di-substituted nsaid derivatives as abeta 42 lowering agents | MERCK SHARP & DOHME CORP. | 2006-03-23 | — | — | US | disclosed |
| EP-1587798-A2 | GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS | Merck & Co., Inc. (US) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004064771-A2 | GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS | MERCK & CO., INC. (US) | 2004-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063937-A1 | Geminallyl di-substituted nsaid derivatives as abeta 42 lowering agents | APP, PSEN1, CA1 | AKR1C2 106/4885MTNR1A 352/4885MTNR1B 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.