Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HTR1E | P28566 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5116957 | 0.75 | AKR1C2 (0.58) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL11488805 | 0.74 | HTR6 (0.58) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL9267967 | 0.73 | HTR1D (0.62) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL8578417 | 0.73 | AKR1C2 (0.55) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL30523119 | 0.72 | ALDH1A1 (0.65) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL5272319 | 0.72 | AKR1C2 (0.55) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL4245648 | 0.72 | AKR1C2 (0.78) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL31543737 | 0.70 | ALDH1A1 (0.62) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL4720481 | 0.69 | GAA (0.71) | AKR1C2ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL8877634 | 0.69 | ALDH1A1 (0.61) | AKR1C2HTR1DHTR6MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394990-A1 | INDOLINE DERIVATIVES | Kyoto University (JP) | 2011-12-14 | — | — | EP | disclosed |
| US-20110294850-A1 | INDOLINE DERIVATIVES | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294850-A1 | INDOLINE DERIVATIVES | BCHE, ACHE, INMT | AKR1C2 437/4885HTR1D 476/4885HTR6 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.