Sugi Predict

Sugi Predict / Compounds / SCHEMBL5117787

SCHEMBL5117787

SCHEMBL5117787

Cc1ccc(C)c2c(O)c(-c3cc4c(=O)oc5c(C)ccc(C)c5c4o3)c(=O)oc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ESR2 Q92731 13/20 0.40
▸ ESR1 P03372 10/20 0.40
▸ GPR55 Q9Y2T6 2/20 0.38
▸ MEN1 O00255 2/20 0.37
▸ MAOA P21397 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ PLK4 O00444 1/20 0.37
▸ IKBKB O14920 1/20 0.37
▸ AURKA O14965 1/20 0.37
▸ CA12 O43570 1/20 0.37
▸ NUAK1 O60285 1/20 0.37
▸ USP2 O75604 1/20 0.37
▸ GSR P00390 1/20 0.37
▸ EGFR P00533 1/20 0.37
▸ CA1 P00915 1/20 0.37
▸ CA2 P00918 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ ERBB2 P04626 1/20 0.37
▸ TP53 P04637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5125434 0.90 ESR2 (0.38) ESR2ESR1MEN1MAOAKMT2A
SCHEMBL5115083 0.77 NQO1 (0.55) ESR2ESR1CSNK2A2CSNK2BCSNK2A1
SCHEMBL5120320 0.77 ESR2 (0.43) ESR2GPR55MEN1KMT2AMAPT
SCHEMBL5119584 0.76 ESR1 (0.45) ESR2ESR1MEN1MAOAKMT2A
SCHEMBL5126659 0.76 CLK2 (0.50) ESR2ESR1MEN1MAOAKMT2A
SCHEMBL5118711 0.72 CSNK2A2 (0.47) ESR2ESR1MEN1MAOAKMT2A
SCHEMBL5110815 0.72 MAOA (0.43) MEN1MAOAKMT2AKDM4EEGFR
SCHEMBL5118825 0.70 NQO1 (0.52) ESR2ESR1MEN1KMT2AKDM4E
SCHEMBL5730945 0.70 ESR1 (0.46) ESR2ESR1CSNK2A2CSNK2BCSNK2A1
SCHEMBL5124620 0.69 ESR2 (0.46) ESR2ESR1MEN1MAOAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7384975-B2 Substituted furochromenes, preparation thereof and their antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2008-06-10 — — US claimed
US-20060148889-A1 Substituted furochromenes, preparation thereof and their antiinflammatory action PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) 2006-07-06 — — US claimed
US-7384975-B2 Substituted furochromenes, preparation thereof and their antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2008-06-10 — — US disclosed
US-7384975-B2 Substituted furochromenes, preparation thereof and their antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2008-06-10 — — US disclosed
US-7384975-B2 Substituted furochromenes, preparation thereof and their antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2008-06-10 — — US disclosed
US-20060148889-A1 Substituted furochromenes, preparation thereof and their antiinflammatory action PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) 2006-07-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060148889-A1 Substituted furochromenes, preparation thereof and their antiinflammatory action CYP11B2, CYP11B1, LTC4S ESR2 962/4885ESR1 1942/4885GPR55 854/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.