Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 5/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 5/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 5/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513294 | 0.84 | HTR7 (0.51) | RAB9ASMN1; SMN2NPC1L3MBTL1HTR7 | |
| SCHEMBL512779 | 0.78 | MAOA (0.44) | RAB9ASMN1; SMN2NPC1TDP1L3MBTL1 | |
| SCHEMBL513422 | 0.73 | NR1H4 (0.45) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL14931923 | 0.73 | RAB9A (0.46) | RAB9ASMN1; SMN2NPC1TDP1L3MBTL1 | |
| SCHEMBL10475798 | 0.72 | RAB9A (0.47) | RAB9ASMN1; SMN2NPC1L3MBTL1HTR7 | |
| SCHEMBL4226837 | 0.72 | RAB9A (0.40) | RAB9ASMN1; SMN2NPC1TDP1L3MBTL1 | |
| SCHEMBL7958860 | 0.71 | SMN1; SMN2 (0.65) | RAB9ASMN1; SMN2NPC1TDP1L3MBTL1 | |
| SCHEMBL514095 | 0.71 | HRH3 (0.35) | HTR7HTR2CPLAT | |
| SCHEMBL3109486 | 0.71 | SMN1; SMN2 (0.64) | RAB9ASMN1; SMN2NPC1TDP1L3MBTL1 | |
| SCHEMBL513177 | 0.70 | HDAC4 (0.53) | SMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477981-A1 | HETEROCYCLIC MGLU5 ANTAGONISTS | Recordati Ireland Limited (IE) | 2012-07-25 | — | — | EP | disclosed |
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | RAB9A 2058/4885SMN1; SMN2 411/4885NPC1 4017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.