Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.42 |
| ▸ | HTR2B | P41595 | 10/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5139829 | 1.00 | HTR2C (0.42) | HTR2CHTR2BBTKFPR2SCN9A | |
| SCHEMBL3839546 | 0.87 | KDM4E (0.41) | HTR2CHTR2BFFAR1MEN1KMT2A | |
| SCHEMBL3840556 | 0.87 | OPRK1 (0.42) | HTR2CHTR2BBTKSLC6A4SLC6A2 | |
| SCHEMBL5133016 | 0.87 | FFAR1 (0.45) | HTR2CHTR2BSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL3881602 | 0.83 | MEN1 (0.43) | FFAR1MEN1KMT2A | |
| SCHEMBL3846234 | 0.81 | ESRRA (0.41) | SLC6A4SLC6A2FFAR1 | |
| SCHEMBL3844103 | 0.81 | BTK (0.39) | BTKFPR2SCN9ASLC6A4HRH3 | |
| SCHEMBL3844268 | 0.81 | POLB (0.42) | FFAR1MEN1KMT2A | |
| SCHEMBL3843530 | 0.80 | FFAR1 (0.46) | HTR2CHTR2BBTKFFAR1 | |
| SCHEMBL3841290 | 0.80 | ALDH1A1 (0.47) | SLC6A4SLC6A2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007136668-A9 | N-BENZOYL-AND N-BENZYLPYRROLIDIN-3-YLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH CORP (US) | 2008-03-27 | — | — | WO | disclosed |