SCHEMBL5131645

SCHEMBL5131645

CC(c1ccc([N+](=O)[O-])cc1)C(N)(CC=O)C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 2/20 0.41
AKR1C2 P52895 2/20 0.41
ALDH1A1 P00352 7/20 0.40
KDM4E B2RXH2 2/20 0.40
NPC1 O15118 1/20 0.40
MAPT P10636 3/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
HPGD P15428 1/20 0.39
USP2 O75604 1/20 0.38
LMNA P02545 1/20 0.38
GRM8 O00222 1/20 0.38
GRM6 O15303 1/20 0.38
GRM4 Q14833 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
TDP1 Q9NUW8 1/20 0.37
GAA P10253 1/20 0.37
HTT P42858 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8714547 0.82 CYP2D6 (0.41) MEN1KMT2A
SCHEMBL5131629 0.76 ALDH1A1 (0.43) AKR1C3AKR1C2ALDH1A1KDM4ENPC1
SCHEMBL2234350 0.74 ALDH1A1 (0.53) AKR1C3AKR1C2ALDH1A1KDM4ENPC1
SCHEMBL5131636 0.74 ALDH1A1 (0.40) AKR1C3AKR1C2ALDH1A1NPC1MAPT
SCHEMBL4416356 0.74 ALDH1A1 (0.51) ALDH1A1KDM4ENPC1MAPTMEN1
SCHEMBL11273135 0.73 LOXL2 (0.46) ALDH1A1KDM4ENPC1MAPTMEN1
SCHEMBL11273163 0.73 LOXL2 (0.46) ALDH1A1KDM4ENPC1MAPTMEN1
SCHEMBL8644843 0.72 ALDH1A1 (0.47) ALDH1A1KDM4ENPC1MAPTMEN1
SCHEMBL1810690 0.71 ALDH1A1 (0.44) AKR1C3AKR1C2ALDH1A1KDM4ENPC1
SCHEMBL5014848 0.71 ARG1 (0.46) KDM4EMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1942949-A1 METHOD FOR THE SYNTHESIS OF PENTAPENDANT ENANTIOMER-PURE CHELATORS AND PROCESS FOR THERAPEUTICALLY ACTIVE BIO-CONJUGATES PREPARATION BY A COVALENT BINDING OF THEREOF Therapharm GmbH (CH) 2008-07-16 EP disclosed
WO-2007028639-A1 METHOD FOR THE SYNTHESIS OF PENTAPENDANT ENANTIOMER-PURE CHELATORS AND PROCESS FOR THERAPEUTICALLY ACTIVE BIO-CONJUGATES PREPARATION BY A COVALENT BINDING OF THEREOF THERAPHARM GMBH (CH) 2007-03-15 WO disclosed