Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.35 |
| ▸ | GLP1R | P43220 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3412817 | 0.86 | SMN1; SMN2 (0.42) | LMNAKDM4EALOX15TSHRSMN1; SMN2 | |
| SCHEMBL4097398 | 0.84 | KDM4E (0.38) | LMNAKDM4EALOX15TSHRSMN1; SMN2 | |
| SCHEMBL4098123 | 0.83 | DDB1 (0.39) | BRS3LMNAKDM4EALOX15TSHR | |
| SCHEMBL3409104 | 0.82 | HPGDS (0.39) | BRS3LMNAKDM4EALOX15TSHR | |
| SCHEMBL4105895 | 0.81 | PFKFB3 (0.37) | LMNAKDM4EALOX15TSHRSMN1; SMN2 | |
| SCHEMBL4104986 | 0.81 | LMNA (0.39) | LMNAKDM4EALOX15TSHRSMN1; SMN2 | |
| SCHEMBL7602597 | 0.81 | CA1 (0.49) | LMNAKDM4EALOX15TSHRSMN1; SMN2 | |
| SCHEMBL7601995 | 0.81 | BRS3 (0.39) | BRS3LMNAKDM4EALOX15TSHR | |
| SCHEMBL4100057 | 0.81 | FADS1 (0.41) | LMNAKDM4EALOX15TSHRSMN1; SMN2 | |
| SCHEMBL3401353 | 0.81 | PFKFB3 (0.41) | LMNAKDM4EALOX15TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183380-B2 | 2-aminoquinolines | HOFFMANN-LA ROCHE INC. (US) | 2012-05-22 | — | — | US | claimed |
| US-8183380-B2 | 2-aminoquinolines | HOFFMANN-LA ROCHE INC. (US) | 2012-05-22 | — | — | US | disclosed |