Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.37 |
| ▸ | GLP1R | P43220 | 1/20 | 0.37 |
| ▸ | NAE1 | Q13564 | 3/20 | 0.37 |
| ▸ | UBA3 | Q8TBC4 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | FADS1 | O60427 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4097503 | 0.94 | MET (0.39) | KDM4ELMNAALOX15TSHRSMN1; SMN2 | |
| SCHEMBL3412817 | 0.91 | SMN1; SMN2 (0.42) | KDM4ELMNAALOX15TSHRSMN1; SMN2 | |
| SCHEMBL4105895 | 0.86 | PFKFB3 (0.37) | KDM4ELMNAALOX15TSHRSMN1; SMN2 | |
| SCHEMBL4104986 | 0.86 | LMNA (0.39) | KDM4ELMNAALOX15TSHRSMN1; SMN2 | |
| SCHEMBL4100057 | 0.85 | FADS1 (0.41) | KDM4ELMNAALOX15TSHRSMN1; SMN2 | |
| SCHEMBL3401353 | 0.85 | PFKFB3 (0.41) | KDM4ELMNAALOX15TSHRSMN1; SMN2 | |
| SCHEMBL7602597 | 0.84 | CA1 (0.49) | KDM4ELMNAALOX15TSHRSMN1; SMN2 | |
| SCHEMBL4101413 | 0.84 | FADS1 (0.46) | KDM4ELMNAALOX15TSHRSMN1; SMN2 | |
| SCHEMBL4106792 | 0.84 | HPGDS (0.43) | KDM4ELMNAALOX15TSHRSMN1; SMN2 | |
| SCHEMBL5131994 | 0.84 | BRS3 (0.39) | KDM4ELMNAALOX15TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183380-B2 | 2-aminoquinolines | HOFFMANN-LA ROCHE INC. (US) | 2012-05-22 | — | — | US | claimed |
| US-20090227570-A1 | 2-AMINOQUINOLINES | HOFFMANN-LA ROCHE, INC. | 2009-09-10 | — | — | US | claimed |
| US-8183380-B2 | 2-aminoquinolines | HOFFMANN-LA ROCHE INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-20090227570-A1 | 2-AMINOQUINOLINES | HOFFMANN-LA ROCHE, INC. | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227570-A1 | 2-AMINOQUINOLINES | HTR5A, HTR2C, HTR2A | KDM4E 1399/4885LMNA 2383/4885ALOX15 2553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.