Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1172592 | 0.84 | SIRT6 (0.55) | KCNJ1KCNH2ALDH1A1MAPTHTR2C | |
| SCHEMBL12325546 | 0.82 | MAPT (0.49) | KCNJ1KCNH2ALDH1A1SLC6A9SLC6A5 | |
| SCHEMBL14032320 | 0.81 | DRD2 (0.51) | KCNH2DRD2JAK2JAK1ALDH1A1 | |
| SCHEMBL5131832 | 0.80 | SLC6A9 (0.48) | ALDH1A1SLC6A9SLC6A5MAPT | |
| SCHEMBL27794415 | 0.80 | DRD2 (0.50) | DRD2JAK2JAK1ALDH1A1JAK3 | |
| SCHEMBL5130122 | 0.79 | ALDH1A1 (0.41) | KCNJ1KCNH2ALDH1A1SLC6A9SLC6A5 | |
| SCHEMBL1172676 | 0.78 | SLC6A9 (0.54) | ALDH1A1SLC6A9SLC6A5MAPT | |
| SCHEMBL23355606 | 0.77 | AKR1C3 (0.54) | KCNJ1KCNH2DRD2JAK2JAK3 | |
| SCHEMBL20445316 | 0.77 | ALDH1A1 (0.41) | ALDH1A1KDM4EHTR1AMAPTHTR2A | |
| SCHEMBL3454537 | 0.76 | DRD2 (0.78) | KCNH2DRD2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242663-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | ASTRAZENECA AB (SE) | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242663-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | EPHB4, EPHB1, NME2 | KCNJ1 3420/4885KCNH2 4181/4885DRD2 3458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.