Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.50 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.50 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11989038 | 0.86 | ALDH1A1 (0.61) | LMNACYP3A4MEN1KMT2AGAA | |
| SCHEMBL19733290 | 0.79 | ALDH1A1 (0.55) | LMNACYP3A4MEN1KMT2AGAA | |
| SCHEMBL8779893 | 0.78 | LMNA (0.59) | LMNACYP3A4MEN1KMT2ARAB9A | |
| SCHEMBL8779899 | 0.78 | LMNA (0.59) | LMNACYP3A4MEN1KMT2ARAB9A | |
| SCHEMBL18401347 | 0.78 | BCHE (0.60) | LMNARAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL8779898 | 0.78 | LMNA (0.59) | LMNACYP3A4MEN1KMT2ARAB9A | |
| SCHEMBL7301655 | 0.77 | CYP3A4 (0.58) | LMNACYP3A4MEN1KMT2ARAB9A | |
| SCHEMBL3536707 | 0.76 | TEAD4 (0.55) | LMNACYP3A4MEN1KMT2AGAA | |
| SCHEMBL2016737 | 0.76 | LMNA (0.61) | LMNACYP3A4MEN1KMT2AGAA | |
| SCHEMBL1800355 | 0.76 | CYP3A4 (0.61) | LMNACYP3A4MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993536-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007103755-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |
| EP-1718642-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005082901-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-09 | — | — | WO | disclosed |