Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5133380 | 0.69 | L3MBTL1 (0.43) | MAPTCYP3A4LMNANOS1POLB | |
| SCHEMBL5133488 | 0.68 | MAPT (0.46) | MAPTCYP3A4LMNANOS1POLB | |
| SCHEMBL5396641 | 0.68 | L3MBTL1 (0.69) | MAPTCYP3A4LMNAPOLBALOX15 | |
| SCHEMBL18147848 | 0.66 | RORC (0.47) | MAPTCYP3A4LMNAPOLBHTT | |
| SCHEMBL29394925 | 0.66 | MAPT (1.00) | MAPTCYP3A4LMNANOS1POLB | |
| SCHEMBL148826 | 0.66 | NOS1 (1.00) | MAPTCYP3A4LMNANOS1POLB | |
| SCHEMBL271522 | 0.66 | MAPT (1.00) | MAPTCYP3A4LMNANOS1POLB | |
| SCHEMBL27572716 | 0.66 | MEN1 (0.59) | MAPTCYP3A4LMNANOS1POLB | |
| Hydrochloric Acid SCHEMBL31587195 | 0.65 | NOS1 (0.97) | MAPTCYP3A4LMNANOS1POLB | |
| Bromide SCHEMBL8520491 | 0.65 | NOS1 (0.97) | MAPTCYP3A4LMNANOS1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987028-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | Transtech Pharma, Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007095124-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2007-08-23 | — | — | WO | disclosed |