SCHEMBL5133715

SCHEMBL5133715

O=C(Cc1ccccc1CSSc1ccccn1)ON1C(=O)CCC1=O

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.36
EHMT2 Q96KQ7 1/20 0.36
EHMT1 Q9H9B1 1/20 0.36
APOBEC3G Q9HC16 1/20 0.36
ALDH1A1 P00352 5/20 0.34
RAB9A P51151 5/20 0.34
NPC1 O15118 3/20 0.34
KMT2A Q03164 3/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
MEN1 O00255 2/20 0.34
MAPT P10636 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
POLB P06746 3/20 0.33
HSD17B10 Q99714 2/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
PKM P14618 1/20 0.32
HDAC1 Q13547 1/20 0.31
HDAC2 Q92769 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL43414 0.86 POLB (0.41) LMNAEHMT2EHMT1APOBEC3GALDH1A1
SCHEMBL1746858 0.85 ALDH1A1 (0.35) LMNAEHMT2EHMT1APOBEC3GALDH1A1
SCHEMBL19209537 0.85 APOBEC3G (0.40) LMNAEHMT2EHMT1APOBEC3GALDH1A1
SCHEMBL12092095 0.84 LMNA (0.42) LMNAEHMT2EHMT1APOBEC3GALDH1A1
SCHEMBL42368 0.82 ALDH1A1 (0.44) LMNAEHMT2EHMT1APOBEC3GALDH1A1
SCHEMBL29352062 0.82 ALDH1A1 (0.44) LMNAEHMT2EHMT1APOBEC3GALDH1A1
SCHEMBL2435515 0.81 POLB (0.41) LMNAEHMT2EHMT1APOBEC3GALDH1A1
SCHEMBL29356575 0.81 ALDH1A1 (0.39) LMNAEHMT2EHMT1APOBEC3GALDH1A1
SCHEMBL107907 0.81 ALDH1A1 (0.39) LMNAEHMT2EHMT1APOBEC3GALDH1A1
SCHEMBL8328957 0.80 ALDH1A1 (0.39) LMNAALDH1A1RAB9ANPC1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11576876-B2 Affinity Medicant Conjugate AF CHEMICALS, LLC (US) 2023-02-14 US disclosed
US-20220133649-A1 AFFINITY MEDICANT CONJUGATE Califia Pharma Inc. (US) 2022-05-05 US disclosed
US-20210299063-A1 AFFINITY MEDICANT CONJUGATE AF CHEMICALS, LLC (US) 2021-09-30 US disclosed
US-9944984-B2 High density DNA array COMPLETE GENOMICS, INC. (US) 2018-04-17 US disclosed
US-20170152554-A1 HIGH DENSITY DNA ARRAY COMPLETE GENOMICS, INC. (US) 2017-06-01 US disclosed
EP-1883410-A2 ANTIBODY OR ANTIBODY FRAGMENT COUPLED WITH AN IMMUNOGENIC AGENT INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER) (FR) 2008-02-06 EP disclosed
EP-1758987-A1 METHODS FOR STEM CELL EXPANSION AND DIFFERENTIATION PETER MacCALLUM CANCER INSTITUTE (AU) 2007-03-07 EP disclosed
WO-2006125921-A2 ANTIBODY OR ANTIBODY FRAGMENT COUPLED WITH AN IMMUNOGENIC AGENT INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER IFREMER (FR) 2006-11-30 WO disclosed
WO-2005105985-A1 METHODS FOR STEM CELL EXPANSION AND DIFFERENTIATION PETER MACCALLUM CANCER INSTITUTE (AU) 2005-11-10 WO disclosed
EP-1359937-A4 ALTERED PEPTIDE LIGANDS GENZYME CORP (US) 2004-07-28 EP disclosed
EP-1359937-A1 ALTERED PEPTIDE LIGANDS GENZYME CORPORATION (US) 2003-11-12 EP disclosed
WO-2002070003-A1 ALTERED PEPTIDE LIGANDS GENZYME CORPORATION (US) 2002-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210299063-A1 AFFINITY MEDICANT CONJUGATE FCER2, HDGF, FCGR2A LMNA 3666/4885EHMT2 1488/4885EHMT1 1237/4885
US-20220133649-A1 AFFINITY MEDICANT CONJUGATE FCER2, HDGF, FCGR2A LMNA 3666/4885EHMT2 1488/4885EHMT1 1237/4885
US-11576876-B2 Affinity Medicant Conjugate FCER2, HDGF, FCGR2A LMNA 3666/4885EHMT2 1488/4885EHMT1 1237/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.