Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.67 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.58 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.56 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.55 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.55 |
| ▸ | MMP8 | P22894 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MEP1B | Q16820 | 4/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20168566 | 0.90 | SLC7A5 (0.76) | SLC7A5FOLH1LOXL2CYP4F2CYP4A11 | |
| SCHEMBL5053124 | 0.85 | FOLH1 (0.63) | FOLH1MEP1B | |
| SCHEMBL6687519 | 0.82 | SLC7A5 (0.69) | SLC7A5FOLH1LOXL2CYP4F2CYP4A11 | |
| SCHEMBL14508897 | 0.82 | SLC7A5 (0.65) | SLC7A5FOLH1LOXL2CYP4F2CYP4A11 | |
| SCHEMBL7261388 | 0.80 | SLC7A5 (1.00) | SLC7A5FOLH1LOXL2CYP4F2CYP4A11 | |
| SCHEMBL1790854 | 0.79 | SLC7A5 (0.68) | SLC7A5FOLH1LOXL2CYP4F2CYP4A11 | |
| Hydrochloric Acid SCHEMBL7261662 | 0.79 | SLC7A5 (0.97) | SLC7A5FOLH1LOXL2CYP4F2CYP4A11 | |
| SCHEMBL15609287 | 0.78 | SLC7A5 (0.76) | SLC7A5FOLH1LOXL2CYP4F2CYP4A11 | |
| SCHEMBL13589439 | 0.78 | SLC7A5 (0.76) | SLC7A5FOLH1LOXL2CYP4F2CYP4A11 | |
| SCHEMBL28281252 | 0.78 | SLC7A5 (0.76) | SLC7A5FOLH1LOXL2CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040186081-A1 | Naaladase inhibitors for treating opioid tolerance | GUILFORD PHARMACEUTICALS INC. | 2004-09-23 | — | — | US | claimed |
| WO-2004078180-A2 | NAALADASE INHIBITORS FOR TREATING OPIOID TOLERANCE | GUILFORD PHARMACEUTICALS INC. (US) | 2004-09-16 | — | — | WO | claimed |
| EP-1292601-A2 | NAALADASE INHIBITORS FOR TREATING RETINAL DISORDERS AND GLAUCOMA | GUILFORD PHARMACEUTICALS INC. (US) | 2003-03-19 | — | — | EP | claimed |
| US-20030036534-A1 | Naaladase inhibitors for treating retinal disorders and glaucoma | EISAI INC. | 2003-02-20 | — | — | US | claimed |
| WO-2001092274-A2 | NAALADASE INHIBITORS FOR TREATING RETINAL DISORDERS AND GLAUCOMA | GUILFORD PHARMACEUTICALS INC. (US) | 2001-12-06 | — | — | WO | claimed |
| US-20080311037-A1 | Compounds which bind PSMA and uses thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2008-12-18 | — | — | US | disclosed |
| US-7220780-B2 | Naaladase inhibitors for treating retinal disorders and glaucoma | GUILFORD PHARMACEUTICALS INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-7220780-B2 | Naaladase inhibitors for treating retinal disorders and glaucoma | GUILFORD PHARMACEUTICALS INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-7220780-B2 | Naaladase inhibitors for treating retinal disorders and glaucoma | GUILFORD PHARMACEUTICALS INC. (US) | 2007-05-22 | — | — | US | disclosed |
| WO-2006093991-A1 | COMPOUNDS WHICH BIND PSMA AND USES THEREOF | THE CLEVELAND CLINIC FOUNDATION (US) | 2006-09-08 | — | — | WO | disclosed |
| US-20060009525-A1 | Hydroxamic acids and acyl hydroxamines as NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. | 2006-01-12 | — | — | US | disclosed |
| US-6884907-B2 | Hydroxamic acids and acyl hydroxamines as naaladase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2005-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080311037-A1 | Compounds which bind PSMA and uses thereof | FOLH1, PSMA1, BPHL | SLC7A5 174/4885FOLH1 1/4885LOXL2 867/4885 |
| US-20040186081-A1 | Naaladase inhibitors for treating opioid tolerance | OPRD1, OPRK1, OPRM1 | SLC7A5 2436/4885FOLH1 254/4885LOXL2 1767/4885 |
| US-20030036534-A1 | Naaladase inhibitors for treating retinal disorders and glaucoma | ALDH1A2, GAA, PDE6A | SLC7A5 3160/4885FOLH1 124/4885LOXL2 1329/4885 |
| US-20060009525-A1 | Hydroxamic acids and acyl hydroxamines as NAALADase inhibitors | RIMKLA, NAALAD2, NAAA | SLC7A5 1371/4885FOLH1 5/4885LOXL2 1285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.