Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9353496 | 0.79 | ALDH1A1 (0.41) | L3MBTL1MEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL4654046 | 0.79 | NPSR1 (0.43) | LMNAL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11297916 | 0.79 | NPSR1 (0.43) | LMNAL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11528680 | 0.78 | LMNA (0.42) | LMNAL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11252915 | 0.75 | ALDH1A1 (0.38) | L3MBTL1SMN1; SMN2NPSR1ALDH1A1GLA | |
| SCHEMBL11263580 | 0.74 | POLB (0.43) | L3MBTL1MEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL11528331 | 0.74 | SMN1; SMN2 (0.40) | LMNAL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL264029 | 0.72 | NPSR1 (0.56) | LMNAL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10890513 | 0.72 | LMNA (0.45) | LMNAL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2552349 | 0.71 | L3MBTL1 (0.59) | LMNAL3MBTL1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158985-A4 | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS | BAYER PHARMACEUTICALS CORP (US) | 2008-03-12 | — | — | EP | disclosed |
| EP-1158985-A1 | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS | Bayer Corporation (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000041698-A1 | φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS | BAYER CORPORATION (US) | 2000-07-20 | — | — | WO | disclosed |