Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.35 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27890781 | 0.84 | SLC16A3 (0.38) | ALDH1A1KDM4EL3MBTL1FYNHSD17B10 | |
| SCHEMBL513361 | 0.84 | FYN (0.41) | ALDH1A1KDM4EL3MBTL1FYNHSD17B10 | |
| SCHEMBL2050232 | 0.83 | SREBF2 (0.43) | ALDH1A1KDM4EL3MBTL1FYNHSD17B10 | |
| SCHEMBL14232845 | 0.77 | NPC1 (0.41) | ALDH1A1KDM4EL3MBTL1FYNHSD17B10 | |
| SCHEMBL435263 | 0.77 | ALDH1A1 (0.49) | ALDH1A1KDM4EL3MBTL1FYNHSD17B10 | |
| SCHEMBL513268 | 0.74 | SLC16A3 (0.42) | ALDH1A1KDM4EL3MBTL1FYNGAA | |
| SCHEMBL4548028 | 0.72 | KDM4E (0.58) | ALDH1A1KDM4EL3MBTL1HSD17B10GAA | |
| SCHEMBL4548038 | 0.72 | KDM4E (0.51) | ALDH1A1KDM4EL3MBTL1HSD17B10GAA | |
| SCHEMBL570365 | 0.71 | PIM1 (0.54) | ALDH1A1KDM4EL3MBTL1HSD17B10GAA | |
| SCHEMBL27818920 | 0.70 | FYN (0.37) | ALDH1A1KDM4EL3MBTL1FYNGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477981-A1 | HETEROCYCLIC MGLU5 ANTAGONISTS | Recordati Ireland Limited (IE) | 2012-07-25 | — | — | EP | disclosed |
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | ALDH1A1 2610/4885KDM4E 3490/4885L3MBTL1 1294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.