Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513238 | 0.78 | SMN1; SMN2 (0.41) | ALDH1A1KDM4EL3MBTL1RAB9AHTT | |
| SCHEMBL513979 | 0.76 | TDP1 (0.40) | ALDH1A1KDM4EL3MBTL1RAB9AHTT | |
| SCHEMBL512797 | 0.75 | KDM4E (0.47) | ALDH1A1KDM4ERAB9AHTTHPGD | |
| SCHEMBL4548038 | 0.74 | KDM4E (0.51) | ALDH1A1KDM4EL3MBTL1HDAC3HDAC4 | |
| SCHEMBL4548028 | 0.74 | KDM4E (0.58) | ALDH1A1KDM4EL3MBTL1HDAC3HDAC4 | |
| SCHEMBL514009 | 0.72 | HDAC1 (0.48) | ALDH1A1KDM4EL3MBTL1HDAC3HDAC4 | |
| SCHEMBL27423832 | 0.69 | ALDH1A1 (0.46) | ALDH1A1KDM4EL3MBTL1HDAC3HDAC4 | |
| SCHEMBL513361 | 0.69 | FYN (0.41) | ALDH1A1KDM4EL3MBTL1HPGDLMNA | |
| SCHEMBL570365 | 0.68 | PIM1 (0.54) | ALDH1A1KDM4EL3MBTL1HTTHPGD | |
| SCHEMBL2050232 | 0.68 | SREBF2 (0.43) | ALDH1A1KDM4EL3MBTL1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | ALDH1A1 2610/4885KDM4E 3490/4885L3MBTL1 1294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.