Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.41 |
| ▸ | SLC16A1 | P53985 | 3/20 | 0.41 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | MAX | P61244 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513766 | 0.78 | ALDH1A1 (0.40) | SMN1; SMN2LMNAMEN1KMT2ASLC16A3 | |
| SCHEMBL514454 | 0.77 | SLC16A3 (0.45) | SMN1; SMN2LMNAMEN1ESR1KMT2A | |
| SCHEMBL513268 | 0.75 | SLC16A3 (0.42) | SMN1; SMN2LMNAMEN1ESR1KMT2A | |
| SCHEMBL513313 | 0.68 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAMEN1ESR1KMT2A | |
| SCHEMBL24038948 | 0.67 | MAPT (0.56) | SMN1; SMN2LMNAMEN1KMT2APOLB | |
| SCHEMBL512797 | 0.67 | KDM4E (0.47) | SMN1; SMN2LMNAMEN1ESR1KMT2A | |
| SCHEMBL27946641 | 0.64 | NR1H4 (0.42) | SMN1; SMN2LMNAMEN1ESR1KMT2A | |
| SCHEMBL514009 | 0.64 | HDAC1 (0.48) | SMN1; SMN2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL27929320 | 0.64 | LMNA (0.43) | SMN1; SMN2LMNAMEN1ESR1KMT2A | |
| SCHEMBL27929301 | 0.63 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNAMEN1ESR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | SMN1; SMN2 411/4885LMNA 1601/4885MEN1 483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.