Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | GRK2 | P25098 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5100672 | 0.86 | ALPL (0.49) | CYP3A4CYP2D6CYP2C9CYP11B1CYP11B2 | |
| SCHEMBL5150253 | 0.81 | LTA4H (0.47) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5148418 | 0.81 | CYP11B1 (0.60) | ROCK2ROCK1CYP2D6CYP2C9CYP11B1 | |
| SCHEMBL5096712 | 0.79 | CYP11B1 (0.59) | ROCK2CYP2D6CYP2C9CYP11B1CYP11B2 | |
| SCHEMBL5103794 | 0.78 | HCAR2 (0.54) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5111022 | 0.78 | FGFR1 (0.49) | ROCK2ROCK1CYP11B1CYP11B2GAA | |
| SCHEMBL5109720 | 0.77 | CYP11B1 (0.43) | CYP11B1CYP11B2MAPTS1PR1LMNA | |
| SCHEMBL5096786 | 0.76 | COMT (0.58) | CYP11B1CYP11B2GAAMAPTALPL | |
| SCHEMBL5104030 | 0.75 | LTA4H (0.47) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5156205 | 0.73 | KDM4E (0.49) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008004100-A2 | THERAPEUTIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2008-01-10 | — | — | WO | disclosed |